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dc.rights.licenseembargoen_US
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorIBRAHIMOVA, Vusala
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorZHAO, Hang
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorIBARBOURE, Emmanuel
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGARANGER, Elisabeth
IDREF: 089451740
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2021-04-16T15:17:35Z
dc.date.available2021-04-16T15:17:35Z
dc.date.issued2021-04-15
dc.identifier.issn1521-3773en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26957
dc.description.abstractEnBiomimetic design to afford smart functional biomaterials with exquisite properties represents synthetic challenges and provides unique perspectives. In this context, elastin-like polypeptides (ELPs) recently became highly attractive building blocks in the development of lipoprotein-based membranes. In addition to the bioengineered post-translational modifications of genetically encoded recombinant ELPs developed so far, we report here a simple and versatile method to design biohybrid brush-like lipid-grafted-ELPs using chemical post-modification reactions. We have explored a combination of methionine alkylation and click chemistry to create a new class of hybrid lipoprotein mimics. Our design allowed the formation of biomimetic vesicles with controlled permeability, correlated to the temperature-responsiveness of ELPs.
dc.description.sponsorshipTemperature-responsive polypeptide nanocarriers for abdominal therapies - ANR-17-ENM3-0009en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subject.enbiomimetic membrane
dc.subject.enelastin-like polypeptides
dc.subject.enlipoproteins
dc.subject.enself-assembly
dc.subject.envesicles
dc.title.enThermosensitive vesicles from chemically encoded lipid-grafted elastin-like polypeptides.
dc.title.alternativeAngew Chem Int Ed Englen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/anie.202102807en_US
dc.subject.halChimie/Polymèresen_US
dc.subject.halSciences du Vivant [q-bio]/Biotechnologiesen_US
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]en_US
dc.identifier.pubmed33856091en_US
bordeaux.journalAngewandte Chemie International Editionen_US
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03200716
hal.version1
hal.date.transferred2021-04-16T15:17:40Z
hal.exporttrue
workflow.import.sourcepubmed
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