Thermosensitive vesicles from chemically encoded lipid-grafted elastin-like polypeptides.
dc.rights.license | embargo | en_US |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | IBRAHIMOVA, Vusala | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | ZHAO, Hang | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | IBARBOURE, Emmanuel | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | GARANGER, Elisabeth
IDREF: 089451740 | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
dc.date.accessioned | 2021-04-16T15:17:35Z | |
dc.date.available | 2021-04-16T15:17:35Z | |
dc.date.issued | 2021-04-15 | |
dc.identifier.issn | 1521-3773 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26957 | |
dc.description.abstractEn | Biomimetic design to afford smart functional biomaterials with exquisite properties represents synthetic challenges and provides unique perspectives. In this context, elastin-like polypeptides (ELPs) recently became highly attractive building blocks in the development of lipoprotein-based membranes. In addition to the bioengineered post-translational modifications of genetically encoded recombinant ELPs developed so far, we report here a simple and versatile method to design biohybrid brush-like lipid-grafted-ELPs using chemical post-modification reactions. We have explored a combination of methionine alkylation and click chemistry to create a new class of hybrid lipoprotein mimics. Our design allowed the formation of biomimetic vesicles with controlled permeability, correlated to the temperature-responsiveness of ELPs. | |
dc.description.sponsorship | Temperature-responsive polypeptide nanocarriers for abdominal therapies - ANR-17-ENM3-0009 | en_US |
dc.language.iso | EN | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
dc.subject.en | biomimetic membrane | |
dc.subject.en | elastin-like polypeptides | |
dc.subject.en | lipoproteins | |
dc.subject.en | self-assembly | |
dc.subject.en | vesicles | |
dc.title.en | Thermosensitive vesicles from chemically encoded lipid-grafted elastin-like polypeptides. | |
dc.title.alternative | Angew Chem Int Ed Engl | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1002/anie.202102807 | en_US |
dc.subject.hal | Chimie/Polymères | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Biotechnologies | en_US |
dc.subject.hal | Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft] | en_US |
dc.identifier.pubmed | 33856091 | en_US |
bordeaux.journal | Angewandte Chemie International Edition | en_US |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | Bordeaux INP | en_US |
bordeaux.institution | CNRS | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.import.source | pubmed | |
hal.identifier | hal-03200716 | |
hal.version | 1 | |
hal.date.transferred | 2021-04-16T15:17:40Z | |
hal.export | true | |
workflow.import.source | pubmed | |
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