Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption.
| dc.rights.license | open | en_US |
| dc.contributor.author | MEVEL, Elsa | |
| dc.contributor.author | MERCERON, Christophe | |
| dc.contributor.author | VINATIER, Claire S. | |
| hal.structure.identifier | Unité de Recherche Oenologie [Villenave d'Ornon] [OENO] | |
| dc.contributor.author | KRISA, Stephanie | |
| hal.structure.identifier | Unité de Recherche Oenologie [Villenave d'Ornon] [OENO] | |
| dc.contributor.author | RICHARD, Tristan | |
| dc.contributor.author | MASSON, Martial | |
| dc.contributor.author | LESOEUR, Julie | |
| dc.contributor.author | HIVERNAUD, Vincent | |
| dc.contributor.author | GAUTHIER, Olivier | |
| dc.contributor.author | ABADIE, Jérôme | |
| dc.contributor.author | NOURISSAT, Geoffroy | |
| dc.contributor.author | HOUARD, Xavier | |
| dc.contributor.author | WITTRANT, Yohann | |
| dc.contributor.author | URBAN, Nelly | |
| dc.contributor.author | BECK, Laurent | |
| dc.contributor.author | GUICHEUX, Jérôme | |
| dc.date.accessioned | 2021-04-14T08:33:50Z | |
| dc.date.available | 2021-04-14T08:33:50Z | |
| dc.date.issued | 2016-09-19 | |
| dc.identifier.issn | 2045-2322 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26936 | |
| dc.description.abstractEn | Polyphenols exert a large range of beneficial effects in the prevention of age-related diseases. We sought to determine whether an extract of olive and grape seed standardized according to hydroxytyrosol (HT) and procyanidins (PCy) content, exerts preventive anti-osteoathritic effects. To this aim, we evaluated whether the HT/PCy mix could (i) have in vitro anti-inflammatory and chondroprotective actions, (ii) exert anti-osteoarthritis effects in two post-traumatic animal models and (iii) retain its bioactivity after oral administration. Anti-inflammatory and chondroprotective actions of HT/PCy were tested on primary cultured rabbit chondrocytes stimulated by interleukin-1 beta (IL-1β). The results showed that HT/PCy exerts anti-inflammatory and chondroprotective actions in vitro. The preventive effect of HT/PCy association was assessed in two animal models of post-traumatic OA in mice and rabbits. Diet supplementation with HT/PCy significantly decreased the severity of post-traumatic osteoarthritis in two complementary mice and rabbit models. The bioavailability and bioactivity was evaluated following gavage with HT/PCy in rabbits. Regular metabolites from HT/PCy extract were found in sera from rabbits following oral intake. Finally, sera from rabbits force-fed with HT/PCy conserved anti-IL-1β effect, suggesting the bioactivity of this extract. To conclude, HT/PCy extract may be of clinical significance for the preventive treatment of osteoarthritis. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Administration | |
| dc.subject.en | Oral | |
| dc.subject.en | Animals | |
| dc.subject.en | Anterior Cruciate Ligament | |
| dc.subject.en | Biflavonoids | |
| dc.subject.en | Catechin | |
| dc.subject.en | Cyclooxygenase 2 | |
| dc.subject.en | Diet | |
| dc.subject.en | Dinoprostone | |
| dc.subject.en | Disease Models | |
| dc.subject.en | Animal | |
| dc.subject.en | Female | |
| dc.subject.en | Grape Seed Extract | |
| dc.subject.en | Interleukin-1beta | |
| dc.subject.en | Male | |
| dc.subject.en | Mass Spectrometry | |
| dc.subject.en | Matrix Metalloproteinase 13 | |
| dc.subject.en | Metabolome | |
| dc.subject.en | Mice | |
| dc.subject.en | Inbred C57BL | |
| dc.subject.en | Nitric Oxide | |
| dc.subject.en | Nitric Oxide Synthase Type II | |
| dc.subject.en | Olea | |
| dc.subject.en | Osteoarthritis | |
| dc.subject.en | Phenylethyl Alcohol | |
| dc.subject.en | Proanthocyanidins | |
| dc.subject.en | RNA | |
| dc.subject.en | Messenger | |
| dc.subject.en | Rabbits | |
| dc.subject.en | Wounds and Injuries | |
| dc.title.en | Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption. | |
| dc.title.alternative | Sci Rep | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/srep33527 | en_US |
| dc.identifier.pubmed | 27640363 | en_US |
| bordeaux.journal | Scientific Reports | en_US |
| bordeaux.page | 33527 | en_US |
| bordeaux.volume | 6 | en_US |
| bordeaux.hal.laboratories | Oenologie - EA 4577 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2016-09-19&rft.volume=6&rft.spage=33527&rft.epage=33527&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=MEVEL,%20Elsa&MERCERON,%20Christophe&VINATIER,%20Claire%20S.&KRISA,%20Stephanie&RICHARD,%20Tristan&rft.genre=article |
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