ABDELAZIZ MOHAMED, Iman; GADEAU, Alain-Pierre; HASAN, Anwarul; ABDULRAHMAN, Nabeel; MRAICHE, Fatima

doi:10.3390/cells8121558

Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases

HASAN, Anwarul

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Cells. 2019-12-03, vol. 8, n° 12

Resumen en inglés

Osteopontin (OPN) is recognized for its significant roles in both physiological and pathological processes. Initially, OPN was recognized as a cytokine with pro-inflammatory actions. More recently, OPN has emerged as a matricellular protein of the extracellular matrix (ECM). OPN is also known to be a substrate for proteolytic cleavage by several proteases that form an integral part of the ECM. In the adult heart under physiological conditions, basal levels of OPN are expressed. Increased expression of OPN has been correlated with the progression of cardiac remodeling and fibrosis to heart failure and the severity of the condition. The intricate process by which OPN mediates its effects include the coordination of intracellular signals necessary for the differentiation of fibroblasts into myofibroblasts, promoting angiogenesis, wound healing, and tissue regeneration. In this review, we discuss the role of OPN in contributing to the development of cardiac fibrosis and its suitability as a therapeutic target.< Leer menos

Palabras clave en inglés

Biomarkers

Cardiomyopathies

Disease Susceptibility

Fibrosis

Gene Expression Regulation

Heart Diseases

Humans

Osteopontin

Signal Transduction

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https://oskar-bordeaux.fr/handle/20.500.12278/26923

DOI

http://dx.doi.org/10.3390/cells8121558

Centros de investigación

Biologie des maladies cardiovasculaires (BMC) - UMR 1034

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Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis

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Palabras clave en inglés

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Centros de investigación