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dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorORRI, Massimiliano
dc.contributor.authorPINGAULT, Jean-Baptiste
dc.contributor.authorTURECKI, Gustavo
dc.contributor.authorNUYT, Anne-Monique
dc.contributor.authorTREMBLAY, Richard
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOTE, Sylvana
ORCID: 0000-0001-7944-0647
dc.contributor.authorGEOFFROY, Marie-Claude
dc.date.accessioned2021-03-30T13:53:36Z
dc.date.available2021-03-30T13:53:36Z
dc.date.issued2021-02-15
dc.identifier.issn0007-1250en_US
dc.identifier.urioai:crossref.org:10.1192/bjp.2021.15
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26834
dc.description.abstractEnBackground Low birth weight is associated with adult mental health, cognitive and socioeconomic problems. However, the causal nature of these associations remains difficult to establish owing to confounding. Aims To estimate the contribution of birth weight to adult mental health, cognitive and socioeconomic outcomes using two-sample Mendelian randomisation, an instrumental variable approach strengthening causal inference. Method We used 48 independent single-nucleotide polymorphisms as genetic instruments for birth weight (genome-wide association studies’ total sample: n = 264 498) and considered mental health (attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder, bipolar disorder, major depressive disorder, obsessive–compulsive disorder, post-traumatic stress disorder (PTSD), schizophrenia, suicide attempt), cognitive (intelligence) and socioeconomic (educational attainment, income, social deprivation) outcomes. Results We found evidence for a contribution of birth weight to ADHD (OR for 1 s.d. unit decrease (~464 g) in birth weight, 1.29; 95% CI 1.03–1.62), PTSD (OR = 1.69; 95% CI 1.06–2.71) and suicide attempt (OR = 1.39; 95% CI 1.05–1.84), as well as for intelligence (β = −0.07; 95% CI −0.13 to −0.02) and socioeconomic outcomes, i.e. educational attainment (β = −0.05; 95% CI −0.09 to −0.01), income (β = −0.08; 95% CI −0.15 to −0.02) and social deprivation (β = 0.08; 95% CI 0.03–0.13). However, no evidence was found for a contribution of birth weight to the other examined mental health outcomes. Results were consistent across a wide range of sensitivity analyses. Conclusions These findings support the hypothesis that birth weight could be an important element on the causal pathway to mental health, cognitive and socioeconomic outcomes.
dc.language.isoENen_US
dc.sourcecrossref
dc.subject.enPsychiatric disorders
dc.subject.enBirth weight
dc.subject.enMendelian randomisation
dc.subject.enSocioeconomic outcomes
dc.subject.enIntelligence
dc.title.enContribution of birth weight to mental health, cognitive and socioeconomic outcomes: two-sample Mendelian randomisation
dc.title.alternativeBr J Psychiatryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1192/bjp.2021.15en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33583444en_US
bordeaux.journalBritish Journal of Psychiatryen_US
bordeaux.page1-8en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
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