Association of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GRASSET, Leslie | |
| dc.contributor.author | SMIT, R. A. J. | |
| dc.contributor.author | CAUNCA, M. R. | |
| dc.contributor.author | ELFASSY, T. | |
| dc.contributor.author | ODDEN, M. C. | |
| dc.contributor.author | VAN DER GROND, J. | |
| dc.contributor.author | VAN BUCHEM, M. A. | |
| dc.contributor.author | STOTT, D. J. | |
| dc.contributor.author | SATTAR, N. | |
| dc.contributor.author | TROMPET, S. | |
| dc.contributor.author | JUKEMA, J. W. | |
| dc.contributor.author | ZEKI AL HAZZOURI, A. | |
| dc.date.accessioned | 2021-03-23T09:13:58Z | |
| dc.date.available | 2021-03-23T09:13:58Z | |
| dc.date.issued | 2020-10 | |
| dc.identifier.issn | 1552-6887 (Electronic) 0898-2643 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26784 | |
| dc.description.abstractEn | Objective: We aimed to examine whether variability in high-density lipoprotein cholesterol (HDL-c) over time was associated with cognitive function. Method: We conducted a post hoc analysis of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial. Our sample included 4,428 participants with at least two repeated HDL-c measures between Months 3 and 24 postbaseline and with cognitive assessments at Month 30. HDL-c variability was defined as the intraindividual standard deviation over each person's repeated measurements. Results: Higher HDL-c variability was associated with worse performance on the Letter-Digit Coding Test (β [95% confidence interval] [CI] = -4.39 [-7.36, -1.43], p = .004), immediate recall on the 15-Picture Learning Test (β [95% CI] = -0.98 [-1.86, -0.11], p = .027), and delayed recall on the 15-Picture Learning Test (β [95% CI] = -1.90 [-3.14, -0.67], p = .002). The associations did not vary by treatment group. Discussion: Our findings suggest that variability in HDL-c may be associated with poor cognitive function among older adults. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Association of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk | |
| dc.title.alternative | J Aging Health | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1177/0898264320916959 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 32456512 | en_US |
| bordeaux.journal | Journal of Aging and Health | en_US |
| bordeaux.page | 1267-1274 | en_US |
| bordeaux.volume | 32 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 9 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | VINTAGE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03177372 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-23T09:14:01Z | |
| hal.export | true | |
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