Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones
| dc.rights.license | embargo | en_US |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | SALAS-AMBROSIO, Pedro | |
| hal.structure.identifier | Laboratoire de chimie de coordination [LCC] | |
| hal.structure.identifier | Pathogénèse des Bactéries Anaérobies / Pathogenesis of Bacterial Anaerobes [PBA (U-Pasteur_6)] | |
| dc.contributor.author | TRONNET, Antoine | |
| hal.structure.identifier | Centre d'Etudes et de Recherche sur le Médicament de Normandie [CERMN] | |
| dc.contributor.author | SINCE, Marc | |
| hal.structure.identifier | Pharmacochimie et Biologie pour le Développement [PHARMA-DEV] | |
| dc.contributor.author | BOURGEADE-DELMAS, Sandra | |
| hal.structure.identifier | Laboratoire de chimie de coordination [LCC] | |
| hal.structure.identifier | Université Toulouse III - Paul Sabatier [UT3] | |
| dc.contributor.author | STIGLIANI, Jean-Luc | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | VAX, Amelie | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LECOMMANDOUX, Sebastien | |
| hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
| hal.structure.identifier | Pathogénèse des Bactéries Anaérobies / Pathogenesis of Bacterial Anaerobes [PBA (U-Pasteur_6)] | |
| dc.contributor.author | DUPUY, Bruno | |
| hal.structure.identifier | Laboratoire de chimie de coordination [LCC] | |
| hal.structure.identifier | Université Toulouse III - Paul Sabatier [UT3] | |
| dc.contributor.author | VERHAEGHE, Pierre | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | BONDUELLE, Colin
IDREF: 134527046 | |
| dc.date.accessioned | 2021-03-18T14:33:02Z | |
| dc.date.available | 2021-03-18T14:33:02Z | |
| dc.date.issued | 2021-03-02 | |
| dc.identifier.issn | 0002-7863 | en_US |
| dc.identifier.uri | oai:crossref.org:10.1021/jacs.0c13231 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26740 | |
| dc.description.abstractEn | Cyclic polymers display unique physicochemical and biological properties. However, their development is often limited by their challenging preparation. In this work, we present a simple route to cyclic poly(α-peptoids) from N-alkylated-N-carboxyanhydrides (NNCA) using LiHMDS promoted ring-expansion polymerization (REP) in DMF. This new method allows the unprecedented use of lysine-like monomers in REP to design bioactive macrocycles bearing pharmaceutical potential against Clostridioides difficile, a bacterium responsible for nosocomial infections. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
| dc.source | crossref | |
| dc.subject | Ring expansion polymerization (REP) | |
| dc.subject.en | Macrocyclic polypeptoids | |
| dc.subject.en | Clostridioides difficile | |
| dc.title.en | Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1021/jacs.0c13231 | en_US |
| dc.subject.hal | Chimie/Polymères | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie | en_US |
| dc.identifier.pubmed | 33651603 | en_US |
| bordeaux.journal | Journal of the American Chemical Society | en_US |
| bordeaux.page | 3697-3702 | en_US |
| bordeaux.volume | 143 | en_US |
| bordeaux.issue | 10 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | dissemin | |
| hal.identifier | hal-03173586 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-18T14:33:07Z | |
| hal.export | true | |
| workflow.import.source | dissemin | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20the%20American%20Chemical%20Society&rft.date=2021-03-02&rft.volume=143&rft.issue=10&rft.spage=3697-3702&rft.epage=3697-3702&rft.eissn=0002-7863&rft.issn=0002-7863&rft.au=SALAS-AMBROSIO,%20Pedro&TRONNET,%20Antoine&SINCE,%20Marc&BOURGEADE-DELMAS,%20Sandra&STIGLIANI,%20Jean-Luc&rft.genre=article |
