SALAS-AMBROSIO, Pedro; TRONNET, Antoine; SINCE, Marc; BOURGEADE-DELMAS, Sandra; STIGLIANI, Jean-Luc; VAX, Amelie; LECOMMANDOUX, Sebastien; DUPUY, Bruno; VERHAEGHE, Pierre; BONDUELLE, Colin

doi:10.1021/jacs.0c13231

SALAS-AMBROSIO, Pedro
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

TRONNET, Antoine
Laboratoire de chimie de coordination [LCC]
Pathogénèse des Bactéries Anaérobies / Pathogenesis of Bacterial Anaerobes [PBA (U-Pasteur_6)]

SINCE, Marc
Centre d'Etudes et de Recherche sur le Médicament de Normandie [CERMN]

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Article de revue

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Journal of the American Chemical Society. 2021-03-02, vol. 143, n° 10, p. 3697-3702

Resumen en inglés

Cyclic polymers display unique physicochemical and biological properties. However, their development is often limited by their challenging preparation. In this work, we present a simple route to cyclic poly(α-peptoids) from N-alkylated-N-carboxyanhydrides (NNCA) using LiHMDS promoted ring-expansion polymerization (REP) in DMF. This new method allows the unprecedented use of lysine-like monomers in REP to design bioactive macrocycles bearing pharmaceutical potential against Clostridioides difficile, a bacterium responsible for nosocomial infections.< Leer menos

Palabras clave

Ring expansion polymerization (REP)

Palabras clave en inglés

Macrocyclic polypeptoids

Clostridioides difficile

URI

https://oskar-bordeaux.fr/handle/20.500.12278/26740

DOI

http://dx.doi.org/10.1021/jacs.0c13231

Centros de investigación

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization: Simple Access to Bioactive Backbones