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Long-term risk of hip or forearm fractures in older occasional users of benzodiazepines

dc.rights.licenseopenen_US
dc.contributor.authorCARRIER, Helene
dc.contributor.authorCORTAREDONA, Sebastien
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPHILIPPS, Viviane
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJACQMIN-GADDA, Helene
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDAUBECH-TOURNIER, Marie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorVERDOUX, Helene
dc.contributor.authorVERGER, P.
dc.date.accessioned2021-03-18T08:26:09Z
dc.date.available2021-03-18T08:26:09Z
dc.date.issued2020-11
dc.identifier.issn1365-2125 (Electronic) 0306-5251 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26712
dc.description.abstractEnAIMS: This article sought to study the association between patterns of benzodiazepine (BZD) use and the risk of hip and forearm fractures in people aged 50 and 75 years or more. METHODS: In a representative cohort of the French National Health Insurance Fund of individuals aged 50 years or older) (N=106 437), we followed up BZD dispensing (reflecting their patterns of use) and the most frequent fall-related fractures (hip and forearm) for 8 years. We used joint latent class models to simultaneously identify BZD dispensing trajectories and the risk of fractures in the entire cohort and in those 75 years or older). We used a survival model to estimate the adjusted hazard ratios (aHRs) between these trajectories and the risk of fractures. RESULTS: In the entire cohort, we identified 5 BZD trajectories: "non-users" (76.7% of the cohort); "occasional users" (15.2%); "decreasing users"(2.6%); "late increasing users" (3.0%); and "early increasing users" (2.4%). Compared with non-users, fracture risk was not increased in either occasional users (aHR = 0.99, 95% CI 0.99-1.00) or in decreasing users (aHR = 0.90, 95% CI 0.74-1.08). It was significantly higher in early increasing users (aHR = 1.86, 95% CI 1.62-2.14) and in late increasing users (aHR = 1.39, 95% CI 1.15-1.60). We observed similar trajectories and risk levels in the people older than 75 years. CONCLUSION: Occasional BZD use, which is compatible with current recommendations, was not associated with an excess risk of the most frequent fall-related fractures in people older than 50 or 75 years.
dc.language.isoENen_US
dc.title.enLong-term risk of hip or forearm fractures in older occasional users of benzodiazepines
dc.title.alternativeBr J Clin Pharmacolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/bcp.14307en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32285959en_US
bordeaux.journalBritish Journal of Clinical Pharmacologyen_US
bordeaux.page2155-2164en_US
bordeaux.volume86en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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