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GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly

dc.rights.licenseopenen_US
dc.contributor.authorSLACHEVSKY, A.
dc.contributor.authorZITKO, P.
dc.contributor.authorMARTINEZ-PERNIA, D.
dc.contributor.authorFORNO, G.
dc.contributor.authorCOURT, F. A.
dc.contributor.authorLILLO, P.
dc.contributor.authorVILLAGRA, R.
dc.contributor.authorDURAN-ANIOTZ, C.
dc.contributor.authorPARRAO, T.
dc.contributor.authorASSAR, R.
dc.contributor.authorORELLANA, P.
dc.contributor.authorTOLEDO, C.
dc.contributor.authorRIVERA, R.
dc.contributor.authorIBANEZ, A.
dc.contributor.authorPARRA, M. A.
dc.contributor.authorGONZALEZ-BILLAULT, C.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMIEVA, Helene
dc.contributor.authorTHUMALA, D.
dc.date.accessioned2021-03-16T13:09:17Z
dc.date.available2021-03-16T13:09:17Z
dc.date.issued2020-11-25
dc.identifier.issn1471-2318 (Electronic) 1471-2318 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26679
dc.description.abstractEnBACKGROUND: With the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and the most rapidly growing cause of death in the last 20 years. Cognitive complaint is considered a predictor for cognitive and functional decline, incident mild cognitive impairment, and incident dementia. The GERO cohort is the Chilean core clinical project of the Geroscience Center for Brain Health and Metabolism (GERO). The objective of the GERO cohort is to analyze the rate of functional decline and progression to clinical dementia and their associated risk factors in a community-dwelling elderly with subjective cognitive complaint, through a population-based study. We also aim to undertake clinical research on brain ageing and dementia disorders, to create data and biobanks with the appropriate infrastructure to conduct other studies and facilitate to the national and international scientific community access to the data and samples for research. METHODS: The GERO cohort aims the recruitment of 300 elderly subjects (> 70 years) from Santiago (Chile), following them up for at least 3 years. Eligible people are adults not diagnosed with dementia with subjective cognitive complaint, which are reported either by the participant, a proxy or both. Participants are identified through a household census. The protocol for evaluation is based on a multidimensional approach including socio-demographic, biomedical, psychosocial, neuropsychological, neuropsychiatric and motor assessments. Neuroimaging, blood and stool samples are also obtained. This multidimensional evaluation is carried out in a baseline and 2 follow-ups assessments, at 18 and 36 months. In addition, in months 6, 12, 24, and 30, a telephone interview is performed in order to keep contact with the participants and to assess general well-being. DISCUSSION: Our work will allow us to determine multidimensional risks factors associated with functional decline and conversion to dementia in elderly with subjective cognitive complain. The aim of our GERO group is to establish the capacity to foster cutting edge and multidisciplinary research on aging in Chile including basic and clinical research. TRIAL REGISTRATION: NCT04265482 in ClinicalTrials.gov. Registration Date: February 11, 2020. Retrospectively Registered.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enGERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly
dc.title.alternativeBMC Geriatren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s12877-020-01866-4en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33238908en_US
bordeaux.journalBMC Geriatricsen_US
bordeaux.page505en_US
bordeaux.volume20en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03170724
hal.version1
hal.date.transferred2021-03-16T13:09:21Z
hal.exporttrue
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