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Cerebral alterations in west African HIV and non-HIV adults aged >/=50: an MRI study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBERNARD, Charlotte
dc.contributor.authorDILHARREGUY, B.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFONT, Helene
dc.contributor.authorDIOP, A. N.
dc.contributor.authorTINE, J. M.
dc.contributor.authorDIAKHATE, I. C.
dc.contributor.authorSEYDI, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDABIS, Francois
dc.contributor.authorCATHELINE, G.
dc.contributor.authorBONNET, Fabrice
dc.date.accessioned2021-03-11T13:49:04Z
dc.date.available2021-03-11T13:49:04Z
dc.date.issued2020-12-10
dc.identifier.issn1878-3511 (Electronic) 1201-9712 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26646
dc.description.abstractEnOBJECTIVES: To describe cross-sectionally brain alterations in PLHIV aged above 50 years old, receiving antiretroviral treatment (ART) and living in Senegal in comparison to HIV-negative subjects. METHODS: Twenty PLHIV and 26 HIV-negative subjects with comparable socio-demographic and clinical characteristics underwent an MRI exam (3D-T1 and FLAIR sequences). Global atrophy and White Matter Hyperintensities (WMH) were evaluated. After assessing the feasibility and acceptability of MRI scans in this population, we described atrophy and WHM prevalence and associated factors using logistic regressions. RESULTS: Overall, 43.5% of the study sample were aged >/=60 years, 58.7% were women, and 28.3% had hypertension. The overall prevalence of atrophy and WMH were 19.6% [95%CI: 8.1-31.1] and 30.4% [95%CI: 17.1-43.7], respectively. HIV status had no significant effect on atrophy or WMH. Unemployment and hypertension were significantly associated with atrophy whereas women were less likely to have atrophy. Aged >/=60 years was the only factor associated with WMH. CONCLUSIONS: A high prevalence of atrophy and WMH was observed in West African adults aged over 50 years without a clear HIV impact. As brain MRI studies are critical to better understand cognitive and emotional outcomes, we encourage those studies in older PLHIV in West Africa.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.title.enCerebral alterations in west African HIV and non-HIV adults aged >/=50: an MRI study
dc.title.alternativeInt J Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ijid.2020.12.016en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33310027en_US
bordeaux.journalInternational Journal of Infectious Diseasesen_US
bordeaux.page457-463en_US
bordeaux.volume103en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03166735
hal.version1
hal.date.transferred2021-03-11T13:49:11Z
hal.exporttrue
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