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Early ART Initiation Improves HIV Status Disclosure and Social Support in People Living with HIV, Linked to Care Within a Universal Test and Treat Program in Rural South Africa (ANRS 12249 TasP Trial)

dc.rights.licenseopenen_US
dc.contributor.authorFIORENTINO, Marion
dc.contributor.authorNISHIMWE, Marie
dc.contributor.authorPROTOPOPESCU, Camelia
dc.contributor.authorIWUJI, Collins
dc.contributor.authorOKESOLA, Nonhlanhla
dc.contributor.authorSPIRE, Bruno
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorORNE-GLIEMANN, Joanna
dc.contributor.authorMCGRATH, Nuala
dc.contributor.authorPILLAY, Deenan
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDABIS, Francois
dc.contributor.authorLARMARANGE, Joseph
dc.contributor.authorBOYER, Sylvie
dc.date.accessioned2021-03-08T11:09:01Z
dc.date.available2021-03-08T11:09:01Z
dc.date.issued2020-11-18
dc.identifier.issn1090-7165en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26453
dc.description.abstractEnWe investigated the effect of early antiretroviral treatment (ART) initiation on HIV status disclosure and social support in a cluster-randomized, treatment-as-prevention (TasP) trial in rural South Africa. Individuals identified HIV-positive after home-based testing were referred to trial clinics where they were invited to initiate ART immediately irrespective of CD4 count (intervention arm) or following national guidelines (control arm). We used Poisson mixed effects models to assess the independent effects of (a) time since baseline clinical visit, (b) trial arm, and (c) ART initiation on HIV disclosure (n = 182) and social support (n = 152) among participants with a CD4 count > 500 cells/mm(3) at baseline. Disclosure and social support significantly improved over follow-up in both arms. Disclosure was higher (incidence rate ratio [95% confidence interval]: 1.24 [1.04; 1.48]), and social support increased faster (1.22 [1.02; 1.46]) in the intervention arm than in the control arm. ART initiation improved both disclosure and social support (1.50 [1.28; 1.75] and 1.34 [1.12; 1.61], respectively), a stronger effect being seen in the intervention arm for social support (1.50 [1.12; 2.01]). Besides clinical benefits, early ART initiation may also improve psychosocial outcomes. This should further encourage countries to implement universal test-and-treat strategies.
dc.language.isoENen_US
dc.title.enEarly ART Initiation Improves HIV Status Disclosure and Social Support in People Living with HIV, Linked to Care Within a Universal Test and Treat Program in Rural South Africa (ANRS 12249 TasP Trial)
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s10461-020-03101-yen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33206263en_US
bordeaux.journalAIDS and Behavioren_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamIDLICen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Virales
hal.identifierhal-03162136
hal.version1
hal.date.transferred2021-03-08T11:09:05Z
hal.exporttrue
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