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Improving the Diagnosis of the Frontal Variant of Alzheimer's Disease with the DAPHNE Scale

dc.rights.licenseopenen_US
dc.contributor.authorLEHINGUE, E.
dc.contributor.authorGUENIAT, J.
dc.contributor.authorJOURDAA, S.
dc.contributor.authorHARDOUIN, J. B.
dc.contributor.authorPALLARDY, A.
dc.contributor.authorCOURTEMANCHE, H.
dc.contributor.authorROCHER, L.
dc.contributor.authorETCHARRY-BOUYX, F.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAURIACOMBE, Sophie
dc.contributor.authorMOLLION, H.
dc.contributor.authorFORMAGLIO, M.
dc.contributor.authorROUAUD, O.
dc.contributor.authorBRETONNIÈRE, C.
dc.contributor.authorANTÉRION, C. T.
dc.contributor.authorBOUTOLEAU-BRETONNIÈRE, C.
dc.date.accessioned2021-03-01T13:51:09Z
dc.date.available2021-03-01T13:51:09Z
dc.date.issued2021-01-15
dc.identifier.issn1875-8908 (Electronic) 1387-2877 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26390
dc.description.abstractEnBACKGROUND: The frontal variant of Alzheimer's disease (fAD) is poorly understood and poorly defined. The diagnosis remains challenging. The main differential diagnosis is the behavioral variant of frontotemporal degeneration (bvFTD). For fAD, there is some dissociation between the clinical frontal presentation and imaging and neuropathological studies, which do not always find a specific involvement of the frontal lobes. DAPHNE is a behavioral scale, which demonstrated excellent performance to distinguish between bvFTD and AD. OBJECTIVE: The aim of the present study was to assess the reliability of this new tool to improve the clinical diagnosis of fAD. METHODS: Twenty fAD patients and their caregivers were prospectively included and were compared with 36 bvFTD and 22 AD patients. RESULTS: The three main behavioral disorders in the fAD patients were apathy, loss of empathy, and disinhibition. Three disorders were discriminant because they were less frequent and less severe in the fAD patients than in the bvFTD patients, namely hyperorality, neglect, and perseverations. This specific pattern of behavioral disorders was corroborated by SPECT or 18FDG PET-CT scan that showed that patients with fAD could have a medial frontal hypoperfusion, whereas in bvFTD patients the orbitofrontal cortex was the main involved region, with more diffuse hypoperfusion. CONCLUSION: We demonstrated that DAPHNE had good sensitivity and good specificity to discriminate between the three groups and in particular between fAD and bvFTD patients. DAPHNE is a quick tool that could help clinicians in memory clinics not only to differentiate bvFTD from typical AD but also from fAD.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.title.enImproving the Diagnosis of the Frontal Variant of Alzheimer's Disease with the DAPHNE Scale
dc.title.alternativeJ Alzheimers Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3233/jad-201088en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.journalJournal of Alzheimer's diseaseen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03165503
hal.version1
hal.date.transferred2021-03-10T15:37:54Z
hal.exporttrue
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