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Impact of referral bias on prognostic studies outcomes: insights from a population-based cohort study on infective endocarditis
| dc.rights.license | open | en_US |
| dc.contributor.author | COLLONNAZ, M. | |
| dc.contributor.author | ERPELDING, M. L. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ALLA, Francois | |
| dc.contributor.author | GOEHRINGER, F. | |
| dc.contributor.author | DELAHAYE, F. | |
| dc.contributor.author | IUNG, B. | |
| dc.contributor.author | LE MOING, V. | |
| dc.contributor.author | HOEN, B. | |
| dc.contributor.author | SELTON-SUTY, C. | |
| dc.contributor.author | AGRINIER, N. | |
| dc.date.accessioned | 2021-03-01T13:05:41Z | |
| dc.date.available | 2021-03-01T13:05:41Z | |
| dc.date.issued | 2021-02 | |
| dc.identifier.issn | 1873-2585 (Electronic) 1047-2797 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26382 | |
| dc.description.abstractEn | PURPOSE: Prognostic studies derived from samples of patients managed in tertiary hospitals are subject to referral bias. We aimed to characterise this bias using the example of infective endocarditis (IE). METHODS: We analysed data from a French population-based cohort which included 497 patients with IE in 2008. Patients were admitted directly to a tertiary hospital (group T), or admitted to a non-tertiary hospital and referred to a tertiary hospital (group NTT) or not (group NT). We compared patients' characteristics and survival rates and prognostic factors between groups. RESULTS: Compared to group T (N=291), NTT patients (N=144) were more often males (81.3% vs 72.5%, p=0.046), injection drug users (9.7% vs 4.5%, p=0.033), had more frequent surgical indications (78.5% vs 64.3%, p=0.003). Compared to group NT (N=62), NTT patients were more often males (81.3% vs 67.7%, p=0.034) and had surgical indications more often (78.5% vs 19.4%, p<0.001). One-year survival was higher in (NTT+T) patients than in NT patients (73.0% vs 56.1%, p=0.01). Prognostic factors as well as HR estimates varied across groups. CONCLUSION: When derived from samples mixing patients admitted directly and those referred to tertiary hospitals, validity of characteristics description, survival estimates, and HRs is threatened by referral bias. | |
| dc.language.iso | EN | en_US |
| dc.title.en | Impact of referral bias on prognostic studies outcomes: insights from a population-based cohort study on infective endocarditis | |
| dc.title.alternative | Ann Epidemiol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.annepidem.2020.09.008 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 32950657 | en_US |
| bordeaux.journal | Annals of Epidemiology | en_US |
| bordeaux.page | 29-37 | en_US |
| bordeaux.volume | 54 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | MRISP | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03154956 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-01T13:05:46Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Annals%20of%20Epidemiology&rft.date=2021-02&rft.volume=54&rft.spage=29-37&rft.epage=29-37&rft.eissn=1873-2585%20(Electronic)%201047-2797%20(Linking)&rft.issn=1873-2585%20(Electronic)%201047-2797%20(Linking)&rft.au=COLLONNAZ,%20M.&ERPELDING,%20M.%20L.&ALLA,%20Francois&GOEHRINGER,%20F.&DELAHAYE,%20F.&rft.genre=article |
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