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Higher sRAGE Levels Predict Mortality in Frail Older Adults with Cardiovascular Disease

dc.rights.licenseopenen_US
dc.contributor.authorBUTCHER, L.
dc.contributor.authorCARNICERO, J. A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERES, Karine
ORCID: 0000-0002-0720-0684
IDREF: 080634001
dc.contributor.authorCOLPO, M.
dc.contributor.authorGOMEZ CABRERO, D.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529
IDREF: 058586105
dc.contributor.authorBANDINELLI, S.
dc.contributor.authorGARCIA-GARCIA, F. J.
dc.contributor.authorRODRIGUEZ-MANAS, L.
dc.contributor.authorERUSALIMSKY, J. D.
dc.date.accessioned2021-03-01T11:20:46Z
dc.date.available2021-03-01T11:20:46Z
dc.date.issued2021-01-21
dc.identifier.issn1423-0003 (Electronic) 0304-324X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26381
dc.description.abstractEnINTRODUCTION: The evidence that blood levels of the soluble receptor for advanced glycation end products (sRAGE) predict mortality in people with cardiovascular diseases (CVD) is inconsistent. To clarify this matter, we investigated if frailty status influences this association. METHODS: We analysed data of 1,016 individuals (median age, 75 years) from 3 population-based European cohorts, enrolled in the FRAILOMIC project. Participants were stratified by history of CVD and frailty status. Mortality was recorded during 8 years of follow-up. RESULTS: In adjusted Cox regression models, baseline serum sRAGE was positively associated with an increased risk of mortality in participants with CVD (HR 1.64, 95% CI 1.09-2.49, p = 0.019) but not in non-CVD. Within the CVD group, the risk of death was markedly enhanced in the frail subgroup (CVD-F, HR 1.97, 95% CI 1.18-3.29, p = 0.009), compared to the non-frail subgroup (CVD-NF, HR 1.50, 95% CI 0.71-3.15, p = 0.287). Kaplan-Meier analysis showed that the median survival time of CVD-F with high sRAGE (>1,554 pg/mL) was 2.9 years shorter than that of CVD-F with low sRAGE, whereas no survival difference was seen for CVD-NF. Area under the ROC curve analysis demonstrated that for CVD-F, addition of sRAGE to the prediction model increased its prognostic value. CONCLUSIONS: Frailty status influences the relationship between sRAGE and mortality in older adults with CVD. sRAGE could be used as a prognostic marker of mortality for these individuals, particularly if they are also frail.
dc.language.isoENen_US
dc.title.enHigher sRAGE Levels Predict Mortality in Frail Older Adults with Cardiovascular Disease
dc.title.alternativeGerontologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1159/000512287en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33477147en_US
bordeaux.journalGerontologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03154824
hal.version1
hal.date.transferred2021-03-01T11:20:50Z
hal.exporttrue
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