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Risk of breast cancer associated with long-term exposure to benzo[a]pyrene (BaP) air pollution: Evidence from the French E3N cohort study

dc.rights.licenseopenen_US
dc.contributor.authorAMADOU, A.
dc.contributor.authorPRAUD, D.
dc.contributor.authorCOUDON, T.
dc.contributor.authorDEYGAS, F.
dc.contributor.authorGRASSOT, L.
dc.contributor.authorFAURE, E.
dc.contributor.authorCOUVIDAT, F.
dc.contributor.authorCAUDEVILLE, J.
dc.contributor.authorBESSAGNET, B.
dc.contributor.authorSALIZZONI, P.
dc.contributor.authorGULLIVER, J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
IDREF: 183599128
dc.contributor.authorSEVERI, G.
dc.contributor.authorMANCINI, F. R.
dc.contributor.authorFERVERS, B.
dc.date.accessioned2021-03-01T08:34:05Z
dc.date.available2021-03-01T08:34:05Z
dc.date.issued2021-01-24
dc.identifier.issn1873-6750 (Electronic) 0160-4120 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26369
dc.description.abstractEnBACKGROUND: Benzo[a]pyrene (BaP) is an endocrine-disrupting pollutant formed during incomplete combustion of organic materials. It has been recognized as a reproductive and developmental toxicant, however epidemiological evidence of the long-term effect of ambient air BaP on breast cancer (BC) is limited. Thus we evaluated associations between ambient air BaP exposure and risk of BC, overall and according to menopausal status and molecular subtypes (estrogen receptor negative/positive (ER-/ER+) and progesterone receptor negative/positive (PR-/PR+)), stage and grade of differentiation of BC in the French E3N cohort study. METHODS: Within a nested case-control study of 5222 incident BC cases and 5222 matched controls, annual BaP exposure was estimated using a chemistry-transport model (CHIMERE) and was assigned to the geocoded residential addresses of participants for each year during the 1990-2011 follow-up period. Multivariable conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Overall, cumulative airborne BaP exposure was significantly associated with the overall risk of BC, for each 1 interquartile range (IQR) increase in the concentration levels of BaP (1.42 ng/m(3)), the OR = 1.15 (95% CI: 1.04-1.27). However, by menopausal status, the significant positive association remained only in women who underwent menopausal transition (i.e. premenopausal women at inclusion who became postmenopausal at diagnosis), OR per 1 IQR = 1.20 (95% CI: 1.03-1.40). By hormone receptor status, positive associations were observed for ER+, PR + and ER + PR + BC, with ORs = 1.17 (95% CI: 1.04-1.32), 1.16 (95% CI: 1.01-1.33), and 1.17 (95% CI: 1.01-1.36) per 1 IQR, respectively. There was also a borderline positive association between BaP and grade 3 BC (OR per 1 IQR = 1.15 (95% CI: 0.99-1.34). CONCLUSIONS: We provide evidence of increased risk of BC associated with cumulative BaP exposure, which varied according to menopausal status, hormone receptor status, and grade of differentiation of BC. Our results add further epidemiological evidence to the previous experimental studies suggesting the adverse effects of BaP.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enRisk of breast cancer associated with long-term exposure to benzo[a]pyrene (BaP) air pollution: Evidence from the French E3N cohort study
dc.title.alternativeEnviron Inten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.envint.2021.106399en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed33503556en_US
bordeaux.journalEnvironment internationalen_US
bordeaux.page106399en_US
bordeaux.volume149en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03154549
hal.version1
hal.date.transferred2021-03-01T08:34:13Z
hal.exporttrue
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