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Low serum DHEA-S is associated with impaired lung function in women

dc.rights.licenseopenen_US
dc.contributor.authorPESCE, G.
dc.contributor.authorTRIEBNER, K.
dc.contributor.authorVAN DER PLAAT, D. A.
dc.contributor.authorCOURBON, D.
dc.contributor.authorHUSTAD, S.
dc.contributor.authorSIGSGAARD, T.
dc.contributor.authorNOWAK, D.
dc.contributor.authorHEINRICH, J.
dc.contributor.authorANTO, J. M.
dc.contributor.authorDORADO-ARENAS, S.
dc.contributor.authorMARTINEZ-MORATALLA, J.
dc.contributor.authorGULLON-BLANCO, J. A.
dc.contributor.authorSANCHEZ-RAMOS, J. L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAHERISON-SEMJEN, Chantal
dc.contributor.authorPIN, I.
dc.contributor.authorDEMOLY, P.
dc.contributor.authorGISLASON, T.
dc.contributor.authorTOREN, K.
dc.contributor.authorFORSBERG, B.
dc.contributor.authorLINDBERG, E.
dc.contributor.authorZEMP, E.
dc.contributor.authorJOGI, R.
dc.contributor.authorPROBST-HENSCH, N.
dc.contributor.authorDHARMAGE, S. C.
dc.contributor.authorJARVIS, D.
dc.contributor.authorGARCIA-AYMERICH, J.
dc.contributor.authorMARCON, A.
dc.contributor.authorGOMEZ-REAL, F.
dc.contributor.authorLEYNAERT, B.
dc.date.accessioned2021-02-25T11:04:46Z
dc.date.available2021-02-25T11:04:46Z
dc.date.issued2020
dc.identifier.issn2589-5370en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26349
dc.description.abstractEnBackground Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS). Methods Lung function and serum DHEA-S concentrations were measured in n = 2,045 and n = 1,725 women in 1999–2002 and in 2010–2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999–2002 with incidence of restrictive pattern and airflow limitation in 2010–2013 were also assessed. Findings Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14). Interpretation Low DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectEPICENE
dc.title.enLow serum DHEA-S is associated with impaired lung function in women
dc.title.alternativeEClinicalMedicineen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.eclinm.2020.100389en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32529179en_US
bordeaux.journalEClinicalMedicineen_US
bordeaux.page100389en_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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