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ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma

dc.rights.licenseopenen_US
dc.contributor.authorOPITZ, I.
dc.contributor.authorSCHERPEREEL, A.
dc.contributor.authorBERGHMANS, T.
dc.contributor.authorPSALLIDAS, I.
dc.contributor.authorGLATZER, M.
dc.contributor.authorRIGAU, D.
dc.contributor.authorASTOUL, P.
dc.contributor.authorBOLUKBAS, S.
dc.contributor.authorBOYD, J.
dc.contributor.authorCOOLEN, J.
dc.contributor.authorDE BONDT, C.
dc.contributor.authorDE RUYSSCHER, D.
dc.contributor.authorDURIEUX, V.
dc.contributor.authorFAIVRE-FINN, C.
dc.contributor.authorFENNELL, D. A.
dc.contributor.authorGALATEAU-SALLE, F.
dc.contributor.authorGREILLIER, L.
dc.contributor.authorHODA, M. A.
dc.contributor.authorKLEPETKO, W.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLACOURT, Aude
dc.contributor.authorMCELNAY, P.
dc.contributor.authorMASKELL, N. A.
dc.contributor.authorMUTTI, L.
dc.contributor.authorPAIRON, J. C.
dc.contributor.authorVAN SCHIL, P.
dc.contributor.authorVAN MEERBEECK, J. P.
dc.contributor.authorWALLER, D.
dc.contributor.authorWEDER, W.
dc.contributor.authorPUTORA, P. M.
dc.contributor.authorCARDILLO, G.
dc.date.accessioned2021-02-25T10:30:46Z
dc.date.available2021-02-25T10:30:46Z
dc.date.issued2020
dc.identifier.issn1873-734X (Electronic) 1010-7940 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26346
dc.description.abstractEnThe European Respiratory Society (ERS)/European Society of Thoracic Surgeons (ESTS)/European Association for Cardio-Thoracic Surgery (EACTS)/European Society for Radiotherapy and Oncology (ESTRO) task force brought together experts to update previous 2009 ERS/ESTS guidelines on management of malignant pleural mesothelioma (MPM), a rare cancer with globally poor outcome, after a systematic review of the 2009–2018 literature. The evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluation approach. The evidence syntheses were discussed and recommendations formulated by this multidisciplinary group of experts. Diagnosis: pleural biopsies remain the gold standard to confirm the diagnosis, usually obtained by thoracoscopy but occasionally via image-guided percutaneous needle biopsy in cases of pleural symphysis or poor performance status. Pathology: standard staining procedures are insufficient in ∼10% of cases, justifying the use of specific markers, including BAP-1 and CDKN2A (p16) for the separation of atypical mesothelial proliferation from MPM. Staging: in the absence of a uniform, robust and validated staging system, we advise using the most recent 2016 8th TNM (tumour, node, metastasis) classification, with an algorithm for pretherapeutic assessment. Monitoring: patient’s performance status, histological subtype and tumour volume are the main prognostic factors of clinical importance in routine MPM management. Other potential parameters should be recorded at baseline and reported in clinical trials. Treatment: (chemo)therapy has limited efficacy in MPM patients and only selected patients are candidates for radical surgery. New promising targeted therapies, immunotherapies and strategies have been reviewed. Because of limited data on the best combination treatment, we emphasize that patients who are considered candidates for a multimodal approach, including radical surgery, should be treated as part of clinical trials in MPM-dedicated centres.
dc.language.isoENen_US
dc.subjectEPICENE
dc.title.enERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma
dc.title.alternativeEur J Cardiothorac Surgen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ejcts/ezaa158en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32448904en_US
bordeaux.journalEuropean Journal of Cardio-Thoracic Surgeryen_US
bordeaux.page1-24en_US
bordeaux.volume58en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03152038
hal.version1
hal.date.transferred2021-02-25T10:31:15Z
hal.exporttrue
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