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Real-world evidence in Alzheimer's disease: The ROADMAP Data Cube

dc.rights.licenseopenen_US
dc.contributor.authorJANSSEN, O.
dc.contributor.authorVOS, S. J. B.
dc.contributor.authorGARCIA-NEGREDO, G.
dc.contributor.authorTOCHEL, C.
dc.contributor.authorGUSTAVSSON, A.
dc.contributor.authorSMITH, M.
dc.contributor.authorLY, A.
dc.contributor.authorNELSON, M.
dc.contributor.authorBALDWIN, H.
dc.contributor.authorSUDLOW, C.
dc.contributor.authorBEXELIUS, C.
dc.contributor.authorJINDRA, C.
dc.contributor.authorVACI, N.
dc.contributor.authorBAUERMEISTER, S.
dc.contributor.authorGALLACHER, J.
dc.contributor.authorPONJOAN, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.contributor.authorGARRE OLMO, J.
dc.contributor.authorPEDERSEN, L.
dc.contributor.authorSKOOG, I.
dc.contributor.authorHOTTGENROTH, A.
dc.contributor.authorVISSER, P. J.
dc.contributor.authorVAN DER LEI, J.
dc.contributor.authorDIAZ, C.
dc.date.accessioned2021-02-24T10:25:02Z
dc.date.available2021-02-24T10:25:02Z
dc.date.issued2020
dc.identifier.issn1552-5279 (Electronic) 1552-5260 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26337
dc.description.abstractEnIntroduction The ROADMAP project aimed to provide an integrated overview of European real‐world data on Alzheimer's disease (AD) across the disease spectrum. Methods Metadata were identified from data sources in catalogs of European AD projects. Priority outcomes for different stakeholders were identified through systematic literature review, patient and public consultations, and stakeholder surveys. Results Information about 66 data sources and 13 outcome domains were integrated into a Data Cube. Gap analysis identified cognitive ability, functional ability/independence, behavioral/neuropsychiatric symptoms, treatment, comorbidities, and mortality as the outcomes collected most. Data were most lacking in caregiver‐related outcomes. In general, electronic health records covered a broader, less detailed data spectrum than research cohorts. Discussion This integrated real‐world AD data overview provides an intuitive visual model that facilitates initial assessment and identification of gaps in relevant outcomes data to inform future prospective data collection and matching of data sources and outcomes against research protocols.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectVINTAGE
dc.title.enReal-world evidence in Alzheimer's disease: The ROADMAP Data Cube
dc.title.alternativeAlzheimers Dementen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jalz.2019.09.087en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32157788en_US
bordeaux.journalAlzheimer's and Dementiaen_US
bordeaux.page461-471en_US
bordeaux.volume16en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03150900
hal.version1
hal.date.transferred2021-02-24T10:25:10Z
hal.exporttrue
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