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Long-lasting severe immune dysfunction in Ebola virus disease survivors

dc.rights.licenseopenen_US
dc.contributor.authorWIEDEMANN, A.
dc.contributor.authorFOUCAT, E.
dc.contributor.authorHOCINI, H.
dc.contributor.authorLEFEBVRE, C.
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHEJBLUM, Boris
ORCID: 0000-0003-0646-452X
IDREF: 189970316
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDURAND, Melany
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKRUGER, Miriam
dc.contributor.authorKEITA, A. K.
dc.contributor.authorAYOUBA, A.
dc.contributor.authorMÉLY, S.
dc.contributor.authorFERNANDEZ, J. C.
dc.contributor.authorTOURÉ, A.
dc.contributor.authorFOURATI, S.
dc.contributor.authorLÉVY-MARCHAL, C.
dc.contributor.authorRAOUL, H.
dc.contributor.authorDELAPORTE, E.
dc.contributor.authorKOIVOGUI, L.
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
dc.contributor.authorLACABARATZ, C.
dc.contributor.authorLEVY, Y.
dc.date.accessioned2021-02-23T08:46:17Z
dc.date.available2021-02-23T08:46:17Z
dc.date.issued2020
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26320
dc.description.abstractEnLong-term follow up studies from Ebola virus disease (EVD) survivors (EBOV_S) are lacking. Here, we evaluate immune and gene expression profiles in 35 Guinean EBOV_S from the last West African outbreak, a median of 23 months (IQR [18–25]) after discharge from treatment center. Compared with healthy donors, EBOV_S exhibit increases of blood markers of inflammation, intestinal tissue damage, T cell and B cell activation and a depletion of circulating dendritic cells. All survivors have EBOV-specific IgG antibodies and robust and polyfunctional EBOV-specific memory T-cell responses. Deep sequencing of the genes expressed in blood reveals an enrichment in ‘inflammation’ and ‘antiviral’ pathways. Integrated analyses identify specific immune markers associated with the persistence of clinical symptoms. This study identifies a set of biological and genetic markers that could be used to define a signature of “chronic Ebola virus disease (CEVD)”.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectSISTM
dc.title.enLong-lasting severe immune dysfunction in Ebola virus disease survivors
dc.title.alternativeNat Communen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-020-17489-7
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32709840en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page3730en_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSISTM_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03160838
hal.version1
hal.date.transferred2021-03-23T09:54:30Z
hal.exporttrue
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