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Semantic loss marks early Alzheimer's disease-related neurodegeneration in older adults without dementia

dc.rights.licenseopenen_US
dc.contributor.authorVONK, J. M. J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUTELOUP, Vincent
dc.contributor.authorMANGIN, J. F.
dc.contributor.authorDUBOIS, B.
dc.contributor.authorBLANC, F.
dc.contributor.authorGABELLE, A.
dc.contributor.authorCECCALDI, M.
dc.contributor.authorANNWEILER, C.
dc.contributor.authorKROLAK-SALMON, P.
dc.contributor.authorBELIN, C.
dc.contributor.authorRIVASSEAU-JONVEAUX, T.
dc.contributor.authorJULIAN, A.
dc.contributor.authorSELLAL, F.
dc.contributor.authorMAGNIN, E.
dc.contributor.authorCHUPIN, M.
dc.contributor.authorHABERT, M. O.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHENE, Genevieve
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
dc.date.accessioned2021-02-22T14:08:35Z
dc.date.available2021-02-22T14:08:35Z
dc.date.issued2020
dc.identifier.issn2352-8729 (Print)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26310
dc.description.abstractEnObjective To assess progression of semantic loss in early stages of cognitive decline using semantic and letter fluency performance, and its relation with Alzheimer's disease (AD)‐specific neurodegeneration using longitudinal multimodal neuroimaging measures. Methods Change in verbal fluency was analyzed among 2261 non‐demented individuals with a follow‐up diagnosis of no mild cognitive impairment (MCI), amnestic MCI (aMCI), non‐amnestic MCI (naMCI), or incident dementia, using linear mixed models across 4 years of follow‐up, and relations with magnetic resonance imaging (MRI; n = 1536) and 18F‐fluorodeoxyglucose brain positron emission tomography (18F‐FDG‐PET) imaging (n = 756) using linear regression models across 2 years of follow‐up. Results Semantic fluency declined—fastest in those at higher risk for AD (apolipoprotein E [APOE] e4 carriers, Clinical Dementia Rating score of .5, aMCI, or incident dementia)—while letter fluency did not except for those with incident dementia. Lower baseline semantic fluency was associated with an increase in white matter hyperintensities and total mean cortical thinning over time, and regionally with less hippocampal volume as well as more cortical thinning and reduced 18F‐FDG‐PET uptake in the inferior parietal lobule, entorhinal cortex, isthmus cingulate, and precuneus–posterior cingulate area. In contrast, baseline letter fluency was not associated with change in total nor regional neurodegeneration. Whole‐brain neurodegeneration over time was associated with faster decline in both fluencies, while AD‐specific regions were associated with a faster rate of decline in semantic but not letter fluency. Interpretation This study provides strong evidence of distinctive degeneration of semantic abilities early on in relation to both cognitive decline and AD‐specific neurodegeneration.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectVINTAGE
dc.subjectMORPH3Eus
dc.title.enSemantic loss marks early Alzheimer's disease-related neurodegeneration in older adults without dementia
dc.title.alternativeAlzheimers Dement (Amst)en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/dad2.12066en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32775598en_US
bordeaux.journalAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoringen_US
bordeaux.pagee12066en_US
bordeaux.volume12en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03148797
hal.version1
hal.date.transferred2021-02-22T14:08:40Z
hal.exporttrue
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