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Using network science tools to identify novel diet patterns in prodromal dementia

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSONAWANE, Abhijeet Rajendra
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFEVRE-ARBOGAST, Sophie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRODSTEIN, Francine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGLASS, Kimberly
dc.date.accessioned2021-02-16T14:18:36Z
dc.date.available2021-02-16T14:18:36Z
dc.date.issued2020
dc.identifier.issn1526-632X (Electronic) 0028-3878 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26256
dc.description.abstractEnObjective To use network science to model complex diet relationships a decade before onset of dementia in a large French cohort, the 3-City Bordeaux study. Methods We identified cases of dementia incident to the baseline food frequency questionnaire over 12 years of follow-up. For each case, we randomly selected 2 controls among individuals at risk at the age at case diagnosis and matched for age at diet assessment, sex, education, and season of the survey. We inferred food networks in both cases and controls using mutual information, a measure to detect nonlinear associations, and compared food consumption patterns between groups. Results In the nested case-control study, the mean (SD) duration of follow-up and number of visits were 5.0 (2.5) vs 4.9 (2.6) years and 4.1 (1.0) vs 4.4 (0.9) for cases (n = 209) vs controls (n = 418), respectively. While there were few differences in simple, average food intakes, food networks differed substantially between cases and controls. The network in cases was focused and characterized by charcuterie as the main hub, with connections to foods typical of French southwestern diet and snack foods. In contrast, the network of controls included several disconnected subnetworks reflecting diverse and healthier food choices. Conclusion How foods are consumed (and not only the quantity consumed) may be important for dementia prevention. Differences in predementia diet networks, suggesting worse eating habits toward charcuterie and snacking, were evident years before diagnosis in this cohort. Network methods, which are designed to model complex systems, may advance our understanding of risk factors for dementia.
dc.language.isoENen_US
dc.subjectSISTM
dc.subjectLEHA
dc.title.enUsing network science tools to identify novel diet patterns in prodromal dementia
dc.title.alternativeNeurologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1212/wnl.0000000000009399en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32321763en_US
bordeaux.journalNeurologyen_US
bordeaux.pagee2014-e2025en_US
bordeaux.volume94en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue19en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03143080
hal.version1
hal.date.transferred2021-02-16T14:18:40Z
hal.exporttrue
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