Genetic Susceptibility, Diet Quality, and Two-Step Progression in Drusen Size
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MERLE, Benedicte
ORCID: 0000-0003-1332-0954 | |
| dc.contributor.author | ROSNER, B. | |
| dc.contributor.author | SEDDON, J. M. | |
| dc.date.accessioned | 2021-02-04T15:56:10Z | |
| dc.date.available | 2021-02-04T15:56:10Z | |
| dc.date.issued | 2020 | |
| dc.identifier.issn | 0146-0404 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26142 | |
| dc.description.abstractEn | Purpose: To investigate the relationship of growth in drusen size with genetic susceptibility and adherence to the alternate Mediterranean diet. Methods: Participants in this analysis had complete ocular, genetic, and dietary data with mean follow-up time of 10.2 years in the Age-Related Eye Disease database. Maximal drusen size was graded on an ordinal scale and two-step progression was determined. A genetic risk score using variants associated with advanced AMD and derived from a stepwise regression model yielded 11 variants in 8 genes. Adherence to the alternate Mediterranean diet was assessed using a nine-component score based on intake of vegetables, fruits, legumes, whole cereals, fish, meat, nuts, alcohol, and monounsaturated-to-saturated fatty acids ratio. Multivariate Cox proportional hazards models were used. Results: Among 3023 eligible eyes, 19% had drusen growth. In the stepwise selection, common and rare risk alleles for CFH Y402H, CFH rs1410996, CFH R1210C, C3 R102G, C3 K155Q, and ARMS2/HTRA1, as well as VEGF-A, TIMP3, NPLOC4, and HSPH1 variants were significantly associated with 2-step progression in drusen size, and the C2 E318D protective allele conferred decreased risk, adjusting for other covariates. A higher genetic risk score conferred a higher risk (hazard ratio per 1-unit increase, 2.68; 95% confidence interval, 2.23–3.23; P < 0.001), and a medium/high adherence to alternate Mediterranean diet score (4–9) tended to lower risk (hazard ratio, 0.83; 95% confidence interval, 0.68–0.99; P = 0.049), adjusting for all covariates. Conclusions: Genetic susceptibility was independently related to drusen growth. A Mediterranean-style diet with healthful nutrient-rich foods (fruits, vegetables, legumes and fish), may reduce enlargement of drusen, the hallmark of AMD. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject | LEHA | |
| dc.title.en | Genetic Susceptibility, Diet Quality, and Two-Step Progression in Drusen Size | |
| dc.title.alternative | Invest Ophthalmol Vis Sci | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1167/iovs.61.5.17 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 32407518 | en_US |
| bordeaux.journal | Investigative Ophthalmology & Visual Science | en_US |
| bordeaux.page | 17 | en_US |
| bordeaux.volume | 61 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | LEHA_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03131915 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-02-04T15:56:14Z | |
| hal.export | true | |
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