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Severe toxoplasmosis imported from tropical Africa in immunocompetent patients: A case series

dc.rights.licenseopenen_US
dc.contributor.authorLEROY, J.
dc.contributor.authorHOUZE, S.
dc.contributor.authorDARDE, M. L.
dc.contributor.authorYERA, H.
dc.contributor.authorROSSI, B.
dc.contributor.authorDELHAES, L.
dc.contributor.authorGABRIEL, F.
dc.contributor.authorLOUBET, P.
dc.contributor.authorDELEPLANCQUE, A. S.
dc.contributor.authorSENNEVILLE, E.
dc.contributor.authorAJANA, F.
dc.contributor.authorSENDID, B.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMALVY, Denis
dc.date.accessioned2021-02-03T08:05:30Z
dc.date.available2021-02-03T08:05:30Z
dc.date.issued2020
dc.identifier.issn1873-0442 (Electronic) 1477-8939 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26120
dc.description.abstractEnBackground Toxoplasmosis is a zoonosis caused by the protozoan Toxoplasma gondii. In immunocompetent patients the infection is usually benign. However, cases of severe and even lethal primo-infections are regularly reported in South America. In contrast, data from tropical Africa are fragmentary. Methods Data for French cases of severe toxoplasmosis acquired between 2013 and 2018, in tropical Africa and among immunocompetent patients were collected retrospectively in 2018. Results Four male patients with a mean age of 34-years were identified. All infections originated in West or Central Africa. The clinical presentations were heterogeneous: two patients had severe disseminated toxoplasmosis, of which one presented with chorioretinitis associated with myositis and the other with febrile pneumopathy; one patient presented with post-infectious acute cerebellar ataxia and the final case had general symptoms and skin manifestations. The diagnosis of acute toxoplasmosis was confirmed by serology in four patients. Molecular diagnosis confirmed T. gondii infection in three patients with Africa 1 as the dominant genotype. The infection was cured with anti-infective treatment in all four patients. Ocular sequelae were reported in the two patients with chorioretinitis. Conclusions Imported cases of severe toxoplasmosis in immunocompetent patients are rare in France. However, this aetiology should be evoked rapidly in a patient with a severe infectious syndrome who has recently visited or originated from tropical Africa.
dc.language.isoENen_US
dc.subjectIDLIC
dc.title.enSevere toxoplasmosis imported from tropical Africa in immunocompetent patients: A case series
dc.title.alternativeTravel Med Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.tmaid.2019.101509en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31712179en_US
bordeaux.journalTravel Medicine and Infectious Diseaseen_US
bordeaux.page101509en_US
bordeaux.volume35en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamIDLICen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03129717
hal.version1
hal.date.transferred2021-02-03T08:05:35Z
hal.exporttrue
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