History of lower-limb complications and risk of cancer death in people with type 2 diabetes.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | MOHAMMEDI, Kamel | |
| dc.contributor.author | HARRAP, Stephen | |
| dc.contributor.author | MANCIA, Giuseppe | |
| dc.contributor.author | MARRE, Michel | |
| dc.contributor.author | POULTER, Neil | |
| dc.contributor.author | CHALMERS, John | |
| dc.contributor.author | WOODWARD, Mark | |
| dc.date.accessioned | 2021-02-02T16:23:29Z | |
| dc.date.available | 2021-02-02T16:23:29Z | |
| dc.date.issued | 2021-01-04 | |
| dc.identifier.issn | 1475-2840 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26107 | |
| dc.description.abstractEn | Individuals with diabetes and lower-limb complications are at high risk for cardiovascular and all-cause mortality, but uncertainties remain in terms of cancer-related death in this population. We investigated this relationship in a large cohort of people with type 2 diabetes. We used data from the Action in Diabetes and Vascular Disease: PreterAx and DiamicroN Modified-Release Controlled Evaluation (ADVANCE) study. The primary outcome was adjudicated cancer death; secondary outcomes were overall and site-specific incident cancers, determined according to the International Classification of Diseases Code (ICD-10). We compared outcomes in individuals with (versus without) a baseline history of lower-limb complications (peripheral artery disease (PAD) or sensory peripheral neuropathy) using Cox regression models. Among 11,140 participants (women 42%, mean age 66 years), lower-limb complications were reported at baseline in 4293 (38%) individuals: 2439 (22%) with PAD and 2973 (27%) with peripheral neuropathy. Cancer death occurred in 316 (2.8%) participants during a median of 5.0 (25th-75th percentile, 4.7-5.1) years of follow-up corresponding to 53,550 person-years and an incidence rate of 5.9 (95% CI 5.3-6.6) per 1000 person-years. The risk of cancer death was higher in individuals with (versus without) lower-limb complication [hazard ratio 1.53 (95% CI, 1.21-1.94), p = 0.0004], PAD [1.32 (1.02-1.70), p = 0.03] or neuropathy (1.41 (1.11-1.79), p = 0.004], adjusting for potential confounders and study allocations. PAD, but not neuropathy, was associated with excess risk of incident cancers. PAD and peripheral neuropathy were independently associated with increased 5-year risk of cancer death in individuals with type 2 diabetes. PAD was also associated with increased risk of incident cancers. Our findings provide new evidence on the non-cardiovascular prognostic burden of lower-limb complications in people with type 2 diabetes. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 France (CC BY 3.0 FR) | |
| dc.rights.uri | https://creativecommons.org/licenses/by/3.0/fr/ | |
| dc.subject | article clinique | |
| dc.title.en | History of lower-limb complications and risk of cancer death in people with type 2 diabetes. | |
| dc.title.alternative | Cardiovasc Diabetol | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1186/s12933-020-01198-y | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | |
| dc.identifier.pubmed | 33397352 | en_US |
| bordeaux.journal | Cardiovascular Diabetology | en_US |
| bordeaux.page | 3 | en_US |
| bordeaux.volume | 20 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires - U1034 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03159232 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-04T12:56:45Z | |
| hal.update-error.status | metadataUpdate | |
| hal.export | false | |
| workflow.import.source | pubmed | |
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