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For diabetic type 1 patients, the skin autofluorescence predicts ulcers and amputations

dc.rights.licenseopenen_US
dc.contributor.authorROJUBALLY, Saad
dc.contributor.authorSIMONEAU, Amélie
dc.contributor.authorMONLUN, Marie
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorFOUSSARD, Ninon
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBLANCO, Laurence
dc.contributor.authorDOMENGE, Frédéric
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorMOHAMMEDI, Kamel
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorDUCASSE, Eric
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorCARADU, Caroline
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRIGALLEAU, Vincent
IDREF: 069788146
dc.date.accessioned2021-02-02T16:23:17Z
dc.date.available2021-02-02T16:23:17Z
dc.date.issued2020-11-27
dc.identifier.issn1873-460Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/26106
dc.description.abstractEnWe searched whether the accumulation of Advanced Glycation End-products (AGEs), reflected by the skin autofluorescence (SAF), could predict diabetic foot ulcers (DFUs) during the long-term follow-up of people with type 1 diabetes. During year 2009, we measured the SAF with an AGE-Reader in 206 subjects with type 1 diabetes. DFU and amputations were registered during the 10 following years. The relation between the SAF and later DFU was analyzed by Cox model regression, adjusted for vascular risk factors. The 206 participants were mainly men (55.8%), 51 ± 15 years old, with a 22 ± 13 years diabetes duration. Twelve subjects presented a DFU. Their SAF were higher: 2.61 ± 0.89 AU vs 2.11 ± 0.53 for the others (p = 0.003), related to the risk of DFU (OR:3.69; 95% CI: 1.06-12.79) after adjustment for age, gender, diabetes duration, initial HbA1c, arterial hypertension, history of smoking, blood lipids and use of a statin. Five subjects were amputated, also related to the initial SAF: OR: 11.28 (95% CI: 1.76-79.97) after adjustment for age, gender, duration of diabetes, and HbA1c. The SAF has already been related to diabetic neuropathy and peripheral arterial disease. It predicts DFU in type 1 diabetes, which suggests that AGEs play a role in this highly specific and feared complication.
dc.language.isoENen_US
dc.subjectarticle clinique
dc.title.enFor diabetic type 1 patients, the skin autofluorescence predicts ulcers and amputations
dc.title.alternativeJ Diabetes Complicationsen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jdiacomp.2020.107808en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie
dc.identifier.pubmed33386214en_US
bordeaux.journalJournal of Diabetes and Its Complicationsen_US
bordeaux.page107808en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires - U1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03285316
hal.version1
hal.date.transferred2021-07-13T09:33:00Z
hal.exporttrue
workflow.import.sourcepubmed
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