Serum tenascin-C is independently associated with increased major adverse cardiovascular events and death in individuals with type 2 diabetes: a French prospective cohort
| dc.rights.license | open | en_US |
| dc.contributor.author | GELLEN, B. | |
| dc.contributor.author | THORIN-TRESCASES, N. | |
| dc.contributor.author | THORIN, E. | |
| dc.contributor.author | GAND, E. | |
| dc.contributor.author | SOSNER, P. | |
| dc.contributor.author | BRISHOUAL, S. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RIGALLEAU, Vincent
IDREF: 069788146 | |
| dc.contributor.author | MONTAIGNE, D. | |
| dc.contributor.author | JAVAUGUE, V. | |
| dc.contributor.author | PUCHEU, Y. | |
| dc.contributor.author | GATAULT, P. | |
| dc.contributor.author | PIGUEL, X. | |
| dc.contributor.author | HADJADJ, S. | |
| dc.contributor.author | SAULNIER, P. J. | |
| dc.date.accessioned | 2021-01-26T12:31:28Z | |
| dc.date.available | 2021-01-26T12:31:28Z | |
| dc.date.issued | 2020 | |
| dc.identifier.issn | 1432-0428 (Electronic) 0012-186X (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/26010 | |
| dc.description.abstractEn | Aims/hypothesis: Tenascin-C (TN-C) is an extracellular matrix glycoprotein highly expressed in inflammatory and cardiovascular (CV) diseases. Serum TN-C has not yet been specifically studied in individuals with type 2 diabetes, a condition associated with chronic low-grade inflammation and increased CV disease risk. In this study, we hypothesised that elevated serum TN-C at enrolment in participants with type 2 diabetes would be associated with increased risk of death and major adverse CV events (MACE) during follow-up. Methods: We used a prospective, monocentric cohort of consecutive type 2 diabetes participants (the SURDIAGENE [SUivi Rénal, DIAbète de type 2 et GENEtique] cohort) with all-cause death as a primary endpoint and MACE (CV death, non-fatal myocardial infarction or stroke) as a secondary endpoint. We used a proportional hazard model after adjustment for traditional risk factors and the relative integrated discrimination improvement (rIDI) to assess the incremental predictive value of TN-C for these risk factors. Results: We monitored 1321 individuals (58% men, mean age 64 ± 11 years) for a median of 89 months. During follow-up, 442 individuals died and 497 had MACE. Multivariate Cox analysis showed that serum TN-C concentrations were associated with an increased risk of death (HR per 1 SD: 1.27 [95% CI 1.17, 1.38]; p < 0.0001) and MACE (HR per 1 SD: 1.23 [95% CI 1.13, 1.34]; p < 0.0001). Using TN-C concentrations on top of traditional risk factors, prediction of the risk of all-cause death (rIDI: 8.2%; p = 0.0006) and MACE (rIDI: 6.7%; p = 0.0014) improved significantly, but modestly. Conclusions/interpretation: In individuals with type 2 diabetes, increased serum TN-C concentrations were independently associated with death and MACE. Therefore, including TN-C as a prognostic biomarker could improve risk stratification in these individuals. | |
| dc.language.iso | EN | en_US |
| dc.subject | LEHA | |
| dc.title.en | Serum tenascin-C is independently associated with increased major adverse cardiovascular events and death in individuals with type 2 diabetes: a French prospective cohort | |
| dc.title.alternative | Diabetologia | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s00125-020-05108-5 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 32040670 | en_US |
| bordeaux.journal | Diabetologia | en_US |
| bordeaux.page | 915-923 | en_US |
| bordeaux.volume | 63 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | LEHA_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03121403 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-01-26T12:31:33Z | |
| hal.export | true | |
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