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Molecular determinism of specific anosmia to 2-bromo-4-methylphenol: Explaining the remarkable specific anosmia for 2-bromo-4-methylphenol

dc.rights.licenseopenen_US
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorTEMPERE, Sophie
IDREF: 154752258
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorSCHAAPER, Marie-Hélène
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorLYTRA, Georgia
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorBARBE, Jean-Christophe
ORCID: 0000-0001-6013-4770
IDREF: 244202567
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorRIQUIER, Laurent
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorMARCHAND, Stephanie
hal.structure.identifierUnité de Recherche Oenologie [Villenave d'Ornon] [OENO]
dc.contributor.authorDE REVEL, Gilles
dc.contributor.authorSICARD, Gilles
dc.date.accessioned2021-01-19T15:23:40Z
dc.date.available2021-01-19T15:23:40Z
dc.date.issued2016-12-23
dc.identifier.issn0882-5734en_US
dc.identifier.urioai:crossref.org:10.1002/ffj.3362
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/25875
dc.description.abstractEnSeveral studies have revealed considerable variations in human chemosensory capacities. Considerable interindividual differences in sensitivity to various odorants and specific hyposmias are well known. Many chemical studies have focused on elucidating structure‐odour relationships on the basis of detection threshold measurements. The basic idea of quantitative structure‐activity relationship studies is that a molecule's structure provides information about its biological activity. In a recent sensory assay of 2‐bromo‐4‐methylphenol, Barbe et al. (2014) highlighted a noticeable bimodal distribution of individual sensitivity with large interindividual differences. The aim of the present study was to investigate the link between the chemical structure of 2‐bromo‐4‐methylphenol and this bimodal distribution. The olfactory phenotypes for a selection of six structurally related halogenated compounds were compared using detection thresholds determination. This study revealed that specific anosmia for 2‐bromo‐4‐methylphenol was apparently linked to the halogenated substitution position.
dc.language.isoENen_US
dc.sourcecrossref
dc.subject.en2-bromo-4-methylphenol
dc.subject.enanosmia
dc.subject.endetection threshold
dc.subject.enstructure-odour relationship
dc.title.enMolecular determinism of specific anosmia to 2-bromo-4-methylphenol: Explaining the remarkable specific anosmia for 2-bromo-4-methylphenol
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/ffj.3362en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
bordeaux.journalFlavour and Fragrance Journalen_US
bordeaux.page126-132en_US
bordeaux.volume32en_US
bordeaux.hal.laboratoriesOenologie - EA 4577en_US
bordeaux.issue2en_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
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