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Chronic long-term exposure to cadmium air pollution and breast cancer risk in the French E3N cohort

dc.rights.licenseopenen_US
dc.contributor.authorAMADOU, A.
dc.contributor.authorPRAUD, D.
dc.contributor.authorCOUDON, T.
dc.contributor.authorDANJOU, A. M. N.
dc.contributor.authorFAURE, E.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
IDREF: 183599128
dc.contributor.authorLE ROMANCER, M.
dc.contributor.authorSEVERI, G.
dc.contributor.authorSALIZZONI, P.
dc.contributor.authorMANCINI, F. R.
dc.contributor.authorFERVERS, B.
dc.date.accessioned2021-01-13T08:26:42Z
dc.date.available2021-01-13T08:26:42Z
dc.date.issued2020
dc.identifier.issn1097-0215 (Electronic) 0020-7136 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/23770
dc.description.abstractEnCadmium, due to its estrogen‐like activity, has been suspected to increase the risk of breast cancer; however, epidemiological studies have reported inconsistent findings. We conducted a case–control study (4,059 cases and 4,059 matched controls) nested within the E3N French cohort study to estimate the risk of breast cancer associated with long‐term exposure to airborne cadmium pollution, and its effect according to molecular subtype of breast cancer (estrogen receptor negative/positive [ER−/ER+] and progesterone receptor negative/positive [PR−/PR+]). Atmospheric exposure to cadmium was assessed using a Geographic Information System‐based metric, which included subject's residence‐to‐cadmium source distance, wind direction, exposure duration and stack height. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Overall, there was no significant association between cumulative dose of airborne cadmium exposure and the risk of overall, premenopausal and postmenopausal breast cancer. However, by ER and PR status, inverse associations were observed for ER− (ORQ5 vs. Q1 = 0.63; 95% CI: 0.41–0.95, ptrend = 0.043) and for ER−/PR− breast tumors (ORQ4 vs. Q1 = 0.62; 95% CI: 0.40–0.95, ORQ5 vs. Q1 = 0.68; 95% CI: 0.42–1.07, ptrend = 0.088). Our study provides no evidence of an association between exposure to cadmium and risk of breast cancer overall but suggests that cadmium might be related to a decreased risk of ER− and ER−/PR− breast tumors. These observations and other possible effects linked to hormone receptor status warrant further investigations.
dc.language.isoENen_US
dc.subjectEPICENE
dc.title.enChronic long-term exposure to cadmium air pollution and breast cancer risk in the French E3N cohort
dc.title.alternativeInt J Canceren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/ijc.32257en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30851122en_US
bordeaux.journalInternational Journal of Canceren_US
bordeaux.page341-351en_US
bordeaux.volume146en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamEPICENE_BPH
bordeaux.teamBIOSTAT_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03167424
hal.version1
hal.date.transferred2021-03-12T08:41:24Z
hal.exporttrue
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