Afficher la notice abrégée

Chronic Low-Dose Exposure to Xenoestrogen Ambient Air Pollutants and Breast Cancer Risk: XENAIR Protocol for a Case-Control Study Nested Within the French E3N Cohort

dc.rights.licenseopenen_US
dc.contributor.authorAMADOU, A.
dc.contributor.authorCOUDON, T.
dc.contributor.authorPRAUD, D.
dc.contributor.authorSALIZZONI, P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEVEQUE, Emilie
dc.contributor.authorBOUTRON-RUAULT, M. C.
dc.contributor.authorDANJOU, A. M. N.
dc.contributor.authorMORELLI, X.
dc.contributor.authorLE CORNET, C.
dc.contributor.authorPERRIER, L.
dc.contributor.authorCOUVIDAT, F.
dc.contributor.authorBESSAGNET, B.
dc.contributor.authorCAUDEVILLE, J.
dc.contributor.authorFAURE, E.
dc.contributor.authorMANCINI, F. R.
dc.contributor.authorGULL
dc.date.accessioned2021-01-13T08:20:38Z
dc.date.available2021-01-13T08:20:38Z
dc.date.issued2020
dc.identifier.issn1929-0748 (Print) 1929-0748 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/23769
dc.description.abstractEnBackground: Breast cancer is the most frequent cancer in women in industrialized countries. Lifestyle and environmental factors, particularly endocrine-disrupting pollutants, have been suggested to play a role in breast cancer risk. Current epidemiological studies, although not fully consistent, suggest a positive association of breast cancer risk with exposure to several International Agency for Research on Cancer Group 1 air-pollutant carcinogens, such as particulate matter, polychlorinated biphenyls (PCB), dioxins, Benzo[a]pyrene (BaP), and cadmium. However, epidemiological studies remain scarce and inconsistent. It has been proposed that the menopausal status could modify the relationship between pollutants and breast cancer and that the association varies with hormone receptor status. Objective: The XENAIR project will investigate the association of breast cancer risk (overall and by hormone receptor status) with chronic exposure to selected air pollutants, including particulate matter, nitrogen dioxide (NO2), ozone (O3), BaP, dioxins, PCB-153, and cadmium. Methods: Our research is based on a case-control study nested within the French national E3N cohort of 5222 invasive breast cancer cases identified during follow-up from 1990 to 2011, and 5222 matched controls. A questionnaire was sent to all participants to collect their lifetime residential addresses and information on indoor pollution. We will assess these exposures using complementary models of land-use regression, atmospheric dispersion, and regional chemistry-transport (CHIMERE) models, via a Geographic Information System. Associations with breast cancer risk will be modeled using conditional logistic regression models. We will also study the impact of exposure on DNA methylation and interactions with genetic polymorphisms. Appropriate statistical methods, including Bayesian modeling, principal component analysis, and cluster analysis, will be used to assess the impact of multipollutant exposure. The fraction of breast cancer cases attributable to air pollution will be estimated. Results: The XENAIR project will contribute to current knowledge on the health effects of air pollution and identify and understand environmental modifiable risk factors related to breast cancer risk. Conclusions: The results will provide relevant evidence to governments and policy-makers to improve effective public health prevention strategies on air pollution. The XENAIR dataset can be used in future efforts to study the effects of exposure to air pollution associated with other chronic conditions.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectBiostatistics
dc.title.enChronic Low-Dose Exposure to Xenoestrogen Ambient Air Pollutants and Breast Cancer Risk: XENAIR Protocol for a Case-Control Study Nested Within the French E3N Cohort
dc.title.alternativeJMIR Res Protocen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.2196/15167en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed32930673en_US
bordeaux.journalJMIR Res Protocen_US
bordeaux.pagee15167en_US
bordeaux.volume9en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=JMIR%20Res%20Protoc&rft.date=2020&rft.volume=9&rft.issue=9&rft.spage=e15167&rft.epage=e15167&rft.eissn=1929-0748%20(Print)%201929-0748%20(Linking)&rft.issn=1929-0748%20(Print)%201929-0748%20(Linking)&rft.au=AMADOU,%20A.&COUDON,%20T.&PRAUD,%20D.&SALIZZONI,%20P.&LEFFONDRE,%20Karen&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
BPH_JMIRRP_2020_Amadou.pdf
Taille:
208.4Ko
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée