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Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study

dc.rights.licenseopenen_US
dc.contributor.authorTHARWAT, Dahlia
dc.contributor.authorTROUSSELARD, Marion
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBALES, Melanie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSUTTER-DALLAY, Anne-Laure
dc.contributor.authorFROMAGE, Dominique
dc.contributor.authorSPITZ, Elisabeth
dc.contributor.authorDALLAY, Dominique
dc.contributor.authorHARVEY, Thierry
dc.contributor.authorWELTER, Eric
dc.contributor.authorCOATLEVEN, Frederic
dc.contributor.authorCHERIER, Lydie
dc.contributor.authorTEISSEDRE, Frederique
dc.contributor.authorPOULY, Jean-Luc
dc.contributor.authorDUTHEIL, Frederic
dc.contributor.authorDUFFAUD, Anais M.
dc.date.accessioned2021-01-05T15:50:00Z
dc.date.available2021-01-05T15:50:00Z
dc.date.issued2018-05-03
dc.identifier.issn2044-6055 (Electronic) 2044-6055 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/23676
dc.description.abstractEnINTRODUCTION: The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, repetition of stressor during pregnancy mimics a chronic stress model that is relevant to the study of the allostatic load and the adaptive mechanisms. On the other hand, vulnerability factors reflect a psychological profile mirroring mindfulness functioning (psychological quality that involves bringing one's complete and non-judgemental attention to the present experience on a moment-to-moment basis). This psychological resource is linked to protective and resilient psychic functioning. Thus, PND appears to be a relevant model for studying the mechanisms of chronic stress and vulnerability to psychopathologies.In this article, we present the protocol of an ongoing study (started in May 2017). METHODS AND ANALYSIS: The study is being carried out in five maternities and will involve 260 women. We aim to determine the predictive psychobiological factors for PND emergence and to provide a better insight into the mechanisms involved in chronic stress during pregnancy. We use a multidisciplinary approach that encompasses psychological resources and biophysiological and genetic profiles in order to detect relevant vulnerability biomarkers for chronic stress and the development of PND. To do so, each woman will be involved in the study from her first trimester of pregnancy until 12 months postdelivery. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Ile de France III Ethics Committee, France (2016-A00887-44). We aim to disseminate the findings through international conferences and international peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03088319; Pre-results.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enPharmacoEpi-Drugs
dc.title.enChronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study
dc.title.alternativeBMJ Openen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/bmjopen-2017-018317en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29724735en_US
bordeaux.journalBMJ Openen_US
bordeaux.pagee018317en_US
bordeaux.volume8en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamPharmacoEpi-Drugsen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMJ%20Open&rft.date=2018-05-03&rft.volume=8&rft.issue=5&rft.spage=e018317&rft.epage=e018317&rft.eissn=2044-6055%20(Electronic)%202044-6055%20(Linking)&rft.issn=2044-6055%20(Electronic)%202044-6055%20(Linking)&rft.au=THARWAT,%20Dahlia&TROUSSELARD,%20Marion&BALES,%20Melanie&SUTTER-DALLAY,%20Anne-Laure&FROMAGE,%20Dominique&rft.genre=article


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