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A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

dc.rights.licenseopenen_US
dc.contributor.authorSUNG, Y. J.
dc.contributor.authorWINKLER, T. W.
dc.contributor.authorDE LAS FUENTES, L.
dc.contributor.authorBENTLEY, A. R.
dc.contributor.authorBROWN, M. R.
dc.contributor.authorKRAJA, A. T.
dc.contributor.authorSCHWANDER, K.
dc.contributor.authorNTALLA, I.
dc.contributor.authorGUO, X.
dc.contributor.authorFRANCESCHINI, N.
dc.contributor.authorLU, Y.
dc.contributor.authorCHENG, C. Y.
dc.contributor.authorSIM, X.
dc.contributor.authorVOJINOVIC, D.
dc.contributor.authorMARTEN, J.
dc.contributor.authorMUSANI, S. K.
dc.contributor.authorLI, C.
dc.contributor.authorFEITOSA, M. F.
dc.contributor.authorKILPELAINEN, T. O.
dc.contributor.authorRICHARD, M. A.
dc.contributor.authorNOORDAM, R.
dc.contributor.authorASLIBEKYAN, S.
dc.contributor.authorASCHARD, H.
dc.contributor.authorBARTZ, T. M.
dc.contributor.authorDORAJOO, R.
dc.contributor.authorLIU, Y.
dc.contributor.authorMANNING, A. K.
dc.contributor.authorRANKINEN, T.
dc.contributor.authorSMITH, A. V.
dc.contributor.authorTAJUDDIN, S. M.
dc.contributor.authorTAYO, B. O.
dc.contributor.authorWARREN, H. R.
dc.contributor.authorZHAO, W.
dc.contributor.authorZHOU, Y.
dc.contributor.authorMATOBA, N.
dc.contributor.authorSOFER, T.
dc.contributor.authorALVER, M.
dc.contributor.authorAMINI, M.
dc.contributor.authorBOISSEL, M.
dc.contributor.authorCHAI, J. F.
dc.contributor.authorCHEN, X.
dc.contributor.authorDIVERS, J.
dc.contributor.authorGANDIN, I.
dc.contributor.authorGAO, C.
dc.contributor.authorGIULIANINI, F.
dc.contributor.authorGOEL, A.
dc.contributor.authorHARRIS, S. E.
dc.contributor.authorHARTWIG, F. P.
dc.contributor.authorHORIMOTO, Arvr
dc.contributor.authorHSU, F. C.
dc.contributor.authorJACKSON, A. U.
dc.contributor.authorKAHONEN, M.
dc.contributor.authorKASTURIRATNE, A.
dc.contributor.authorKUHNEL, B.
dc.contributor.authorLEANDER, K.
dc.contributor.authorLEE, W. J.
dc.contributor.authorLIN, K. H.
dc.contributor.authorAN LUAN, J.
dc.contributor.authorMCKENZIE, C. A.
dc.contributor.authorMEIAN, H.
dc.contributor.authorNELSON, C. P.
dc.contributor.authorRAURAMAA, R.
dc.contributor.authorSCHUPF, N.
dc.contributor.authorSCOTT, R. A.
dc.contributor.authorSHEU, W. H. H.
dc.contributor.authorSTANCAKOVA, A.
dc.contributor.authorTAKEUCHI, F.
dc.contributor.authorVAN DER MOST, P. J.
dc.contributor.authorVARGA, T. V.
dc.contributor.authorWANG, H.
dc.contributor.authorWANG, Y.
dc.contributor.authorWARE, E. B.
dc.contributor.authorWEISS, S.
dc.contributor.authorWEN, W.
dc.contributor.authorYANEK, L. R.
dc.contributor.authorZHANG, W.
dc.contributor.authorZHAO, J. H.
dc.contributor.authorAFAQ, S.
dc.contributor.authorALFRED, T.
dc.contributor.authorAMIN, N.
dc.contributor.authorARKING, D.
dc.contributor.authorAUNG, T.
dc.contributor.authorBARR, R. G.
dc.contributor.authorBIELAK, L. F.
dc.contributor.authorBOERWINKLE, E.
dc.contributor.authorBOTTINGER, E. P.
dc.contributor.authorBRAUND, P. S.
dc.contributor.authorBRODY, J. A.
dc.contributor.authorBROECKEL, U.
dc.contributor.authorCABRERA, C. P.
dc.contributor.authorCADE, B.
dc.contributor.authorCAIZHENG, Y.
dc.contributor.authorCAMPBELL, A.
dc.contributor.authorCANOUIL, M.
dc.contributor.authorCHAKRAVARTI, A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHAUHAN, Ganesh
dc.contributor.authorCHRISTENSEN, K.
dc.contributor.authorCOCCA, M.
dc.contributor.authorCOLLINS, F. S.
dc.contributor.authorCONNELL, J. M.
dc.contributor.authorDE MUTSERT, R.
dc.contributor.authorDE SILVA, H. J.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDORR, M.
dc.contributor.authorDUAN, Q.
dc.contributor.authorEATON, C. B.
dc.contributor.authorEHRET, G.
dc.contributor.authorEVANGELOU, E.
dc.contributor.authorFAUL, J. D.
dc.contributor.authorFISHER, V. A.
dc.contributor.authorFOROUHI, N. G.
dc.contributor.authorFRANCO, O. H.
dc.contributor.authorFRIEDLANDER, Y.
dc.contributor.authorGAO, H.
dc.contributor.authorGIGANTE, B.
dc.contributor.authorGRAFF, M.
dc.contributor.authorGU, C. C.
dc.contributor.authorGU, D.
dc.contributor.authorGUPTA, P.
dc.contributor.authorHAGENAARS, S. P.
dc.contributor.authorHARRIS, T. B.
dc.contributor.authorHE, J.
dc.contributor.authorHEIKKINEN, S.
dc.contributor.authorHENG, C. K.
dc.contributor.authorHIRATA, M.
dc.contributor.authorHOFMAN, A.
dc.contributor.authorHOWARD, B. V.
dc.contributor.authorHUNT, S.
dc.contributor.authorIRVIN, M. R.
dc.contributor.authorJIA, Y.
dc.contributor.authorJOEHANES, R.
dc.contributor.authorJUSTICE, A. E.
dc.contributor.authorKATSUYA, T.
dc.contributor.authorKAUFMAN, J.
dc.contributor.authorKERRISON, N. D.
dc.contributor.authorKHOR, C. C.
dc.contributor.authorKOH, W. P.
dc.contributor.authorKOISTINEN, H. A.
dc.contributor.authorKOMULAINEN, P.
dc.contributor.authorKOOPERBERG, C.
dc.contributor.authorKRIEGER, J. E.
dc.contributor.authorKUBO, M.
dc.contributor.authorKUUSISTO, J.
dc.contributor.authorLANGEFELD, C. D.
dc.contributor.authorLANGENBERG, C.
dc.contributor.authorLAUNER, L. J.
dc.contributor.authorLEHNE, B.
dc.contributor.authorLEWIS, C. E.
dc.contributor.authorLI, Y.
dc.contributor.authorLIM, S. H.
dc.contributor.authorLIN, S.
dc.contributor.authorLIU, C. T.
dc.contributor.authorLIU, J.
dc.contributor.authorLIU, J.
dc.contributor.authorLIU, K.
dc.contributor.authorLIU, Y.
dc.contributor.authorLOH, M.
dc.contributor.authorLOHMAN, K. K.
dc.contributor.authorLONG, J.
dc.contributor.authorLOUIE, T.
dc.contributor.authorMAGI, R.
dc.contributor.authorMAHAJAN, A.
dc.contributor.authorMEITINGER, T.
dc.contributor.authorMETSPALU, A.
dc.contributor.authorMILANI, L.
dc.contributor.authorMOMOZAWA, Y.
dc.contributor.authorMORRIS, A. P.
dc.contributor.authorMOSLEY, T. H., Jr.
dc.contributor.authorMUNSON, P.
dc.contributor.authorMURRAY, A. D.
dc.contributor.authorNALLS, M. A.
dc.contributor.authorNASRI, U.
dc.contributor.authorNORRIS, J. M.
dc.contributor.authorNORTH, K.
dc.contributor.authorOGUNNIYI, A.
dc.contributor.authorPADMANABHAN, S.
dc.contributor.authorPALMAS, W. R.
dc.contributor.authorPALMER, N. D.
dc.contributor.authorPANKOW, J. S.
dc.contributor.authorPEDERSEN, N. L.
dc.contributor.authorPETERS, A.
dc.contributor.authorPEYSER, P. A.
dc.contributor.authorPOLASEK, O.
dc.contributor.authorRAITAKARI, O. T.
dc.contributor.authorRENSTROM, F.
dc.contributor.authorRICE, T. K.
dc.contributor.authorRIDKER, P. M.
dc.contributor.authorROBINO, A.
dc.contributor.authorROBINSON, J. G.
dc.contributor.authorROSE, L. M.
dc.contributor.authorRUDAN, I.
dc.contributor.authorSABANAYAGAM, C.
dc.contributor.authorSALAKO, B. L.
dc.contributor.authorSANDOW, K.
dc.contributor.authorSCHMIDT, C. O.
dc.contributor.authorSCHREINER, P. J.
dc.contributor.authorSCOTT, W. R.
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorSEVER, P.
dc.contributor.authorSITLANI, C. M.
dc.contributor.authorSMITH, J. A.
dc.contributor.authorSNIEDER, H.
dc.contributor.authorSTARR, J. M.
dc.contributor.authorSTRAUCH, K.
dc.contributor.authorTANG, H.
dc.contributor.authorTAYLOR, K. D.
dc.contributor.authorTEO, Y. Y.
dc.contributor.authorTHAM, Y. C.
dc.contributor.authorUITTERLINDEN, A. G.
dc.contributor.authorWALDENBERGER, M.
dc.contributor.authorWANG, L.
dc.contributor.authorWANG, Y. X.
dc.contributor.authorWEI, W. B.
dc.contributor.authorWILLIAMS, C.
dc.contributor.authorWILSON, G.
dc.contributor.authorWOJCZYNSKI, M. K.
dc.contributor.authorYAO, J.
dc.contributor.authorYUAN, J. M.
dc.contributor.authorZONDERMAN, A. B.
dc.contributor.authorBECKER, D. M.
dc.contributor.authorBOEHNKE, M.
dc.contributor.authorBOWDEN, D. W.
dc.contributor.authorCHAMBERS, J. C.
dc.contributor.authorCHEN, Y. I.
dc.contributor.authorDE FAIRE, U.
dc.contributor.authorDEARY, I. J.
dc.contributor.authorESKO, T.
dc.contributor.authorFARRALL, M.
dc.contributor.authorFORRESTER, T.
dc.contributor.authorFRANKS, P. W.
dc.contributor.authorFREEDMAN, B. I.
dc.contributor.authorFROGUEL, P.
dc.contributor.authorGASPARINI, P.
dc.contributor.authorGIEGER, C.
dc.contributor.authorHORTA, B. L.
dc.contributor.authorHUNG, Y. J.
dc.contributor.authorJONAS, J. B.
dc.contributor.authorKATO, N.
dc.contributor.authorKOONER, J. S.
dc.contributor.authorLAAKSO, M.
dc.contributor.authorLEHTIMAKI, T.
dc.contributor.authorLIANG, K. W.
dc.contributor.authorMAGNUSSON, P. K. E.
dc.contributor.authorNEWMAN, A. B.
dc.contributor.authorOLDEHINKEL, A. J.
dc.contributor.authorPEREIRA, A. C.
dc.contributor.authorREDLINE, S.
dc.contributor.authorRETTIG, R.
dc.contributor.authorSAMANI, N. J.
dc.contributor.authorSCOTT, J.
dc.contributor.authorSHU, X. O.
dc.contributor.authorVAN DER HARST, P.
dc.contributor.authorWAGENKNECHT, L. E.
dc.contributor.authorWAREHAM, N. J.
dc.contributor.authorWATKINS, H.
dc.contributor.authorWEIR, D. R.
dc.contributor.authorWICKREMASINGHE, A. R.
dc.contributor.authorWU, T.
dc.contributor.authorZHENG, W.
dc.contributor.authorKAMATANI, Y.
dc.contributor.authorLAURIE, C. C.
dc.contributor.authorBOUCHARD, C.
dc.contributor.authorCOOPER, R. S.
dc.contributor.authorEVANS, M. K.
dc.contributor.authorGUDNASON, V.
dc.contributor.authorKARDIA, S. L. R.
dc.contributor.authorKRITCHEVSKY, S. B.
dc.contributor.authorLEVY, D.
dc.contributor.authorO'CONNELL, J. R.
dc.contributor.authorPSATY, B. M.
dc.contributor.authorVAN DAM, R. M.
dc.contributor.authorSIMS, M.
dc.contributor.authorARNETT, D. K.
dc.contributor.authorMOOK-KANAMORI, D. O.
dc.contributor.authorKELLY, T. N.
dc.contributor.authorFOX, E. R.
dc.contributor.authorHAYWARD, C.
dc.contributor.authorFORNAGE, M.
dc.contributor.authorROTIMI, C. N.
dc.contributor.authorPROVINCE, M. A.
dc.contributor.authorVAN DUIJN, C. M.
dc.contributor.authorTAI, E. S.
dc.contributor.authorWONG, T. Y.
dc.contributor.authorLOOS, R. J. F.
dc.contributor.authorREINER, A. P.
dc.contributor.authorROTTER, J. I.
dc.contributor.authorZHU, X.
dc.contributor.authorBIERUT, L. J.
dc.contributor.authorGAUDERMAN, W. J.
dc.contributor.authorCAULFIELD, M. J.
dc.contributor.authorELLIOTT, P.
dc.contributor.authorRICE, K.
dc.contributor.authorMUNROE, P. B.
dc.contributor.authorMORRISON, A. C.
dc.contributor.authorCUPPLES, L. A.
dc.contributor.authorRAO, D. C.
dc.contributor.authorCHASMAN, D. I.
dc.date.accessioned2021-01-05T14:08:27Z
dc.date.available2021-01-05T14:08:27Z
dc.date.issued2018-03-01
dc.identifier.issn1537-6605 (Electronic) 0002-9297 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/23668
dc.description.abstractEnGenome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined approximately 18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p < 5 x 10(-8)) in stage 1 and formally replicated in stage 2. A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively). A total of 56 known BP loci were also identified by our results (p < 5 x 10(-8)). Of the newly identified loci, ten showed significant interaction with smoking status, but none of them were replicated in stage 2. Several loci were identified in African ancestry, highlighting the importance of genetic studies in diverse populations. The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits. They also highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function (CDKN1B, BCAR1-CFDP1, PXDN, EEA1), ciliopathies (SDCCAG8, RPGRIP1L), telomere maintenance (TNKS, PINX1, AKTIP), and central dopaminergic signaling (MSRA, EBF2).
dc.language.isoENen_US
dc.subject.enVINTAGE
dc.title.enA Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
dc.title.alternativeAm J Hum Geneten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ajhg.2018.01.015en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29455858en_US
bordeaux.journalAmerican Journal of Human Geneticsen_US
bordeaux.page375-400en_US
bordeaux.volume102en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03194157
hal.version1
hal.date.transferred2021-04-09T11:19:14Z
hal.exporttrue
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