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APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality

dc.rights.licenseopenen_US
dc.contributor.authorSATIZABAL, C. L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIERI, Cecilia
dc.contributor.authorDAVIS-PLOURDE, K. L.
dc.contributor.authorVOETSCH, B.
dc.contributor.authorAPARICIO, H. J.
dc.contributor.authorPASE, M. P.
dc.contributor.authorROMERO, J. R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorVASAN, R. S.
dc.contributor.authorKASE, C. S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorBEISER, A. S.
dc.contributor.authorSESHADRI, Sudha
dc.date.accessioned2021-01-04T15:58:20Z
dc.date.available2021-01-04T15:58:20Z
dc.date.issued2018-12
dc.identifier.issn1524-4628 (Electronic) 0039-2499 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/23635
dc.description.abstractEnBackground and Purpose- The role of dietary fat on cardiovascular health and mortality remains under debate. Because the APOE is central to the transport and metabolism of lipids, we examined associations between plasma fatty acids and the risk of stroke, coronary heart disease, and mortality by APOE-epsilon4 genotype. Methods- We included 943 FHS (Framingham Heart Study) and 1406 3C (Three-City) Bordeaux Study participants. Plasma docosahexaenoic, linoleic, arachidonic, and palmitic fatty acids were measured at baseline by gas chromatography. All-cause stroke, ischemic stroke, coronary heart disease, and all-cause mortality events were identified prospectively using standardized protocols. Each cohort used Cox models to separately relate fatty acid levels to the risk of developing each event during </=10 years of follow-up adjusting for potential confounders and stratifying by APOE genotype (epsilon4 carriers versus noncarriers). We then meta-analyzed summary statistics using random-effects models. Results- On average, participants had a mean age of 74 years, 61% were women, and 21% (n=483) were APOE-epsilon4 carriers. Meta-analysis results showed that, only among APOE-epsilon4 carriers, every SD unit increase in linoleic acid was associated with a reduced risk of all-cause stroke (hazard ratio [HR], 0.54 [95% CI, 0.38-0.78]), ischemic stroke (HR, 0.48 [95% CI, 0.33-0.71]), and all-cause mortality (HR, 0.70 [95% CI, 0.57-0.85]). In contrast, every SD unit increase in palmitic acid was related to an increased risk of all-cause stroke (HR, 1.58 [95% CI, 1.16-2.17]), ischemic stroke (HR, 1.76 [95% CI, 1.26-2.45]), and coronary heart disease (HR, 1.48 [95% CI, 1.09-2.01]), also in APOE-epsilon4 carriers only. Results for docosahexaenoic acid and arachidonic acid were heterogeneous between cohorts. Conclusions- These exploratory results suggest that APOE-epsilon4 carriers may be more susceptible to the beneficial or adverse impact of fatty acids on cardiovascular disease and mortality. In this subgroup, higher linoleic acid was protective for stroke and mortality, whereas palmitic acid was a risk factor for stroke and coronary heart disease. The mechanisms underlying these novel findings warrant further investigation.
dc.language.isoENen_US
dc.subject.enLEHA
dc.subject.enVINTAGE
dc.title.enAPOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality
dc.title.alternativeStrokeen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1161/STROKEAHA.118.022132en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30571417en_US
bordeaux.journalStrokeen_US
bordeaux.page2822-2829en_US
bordeaux.volume49en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamVINTAGEen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03194004
hal.version1
hal.date.transferred2021-04-09T09:41:30Z
hal.exporttrue
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