Thermosensitive Hybrid Elastin-like Polypeptide-Based ABC Triblock Hydrogel
dc.rights.license | embargo | en_US |
hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | DAI, Michèle | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | GOUDOUNET, Guillaume | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | ZHAO, Hang | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | GARBAY, Bertrand
ORCID: 0000-0001-5756-2627 IDREF: 033777551 | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | GARANGER, Elisabeth
IDREF: 089451740 | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies | |
dc.contributor.author | PECASTAINGS, Gilles | |
hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
dc.contributor.author | SCHULTZE, Xavier | |
hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
dc.contributor.author | LECOMMANDOUX, Sebastien | |
dc.date.accessioned | 2020-12-24T17:05:13Z | |
dc.date.available | 2020-12-24T17:05:13Z | |
dc.date.issued | 2020-11-23 | |
dc.identifier.issn | 0024-9297 | en_US |
dc.identifier.uri | oai:crossref.org:10.1021/acs.macromol.0c01744 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/23599 | |
dc.description.abstractEn | We report the synthesis of a well-defined hybrid ABC triblock terpolymer containing a synthetic poly(trimethylene carbonate) (PTMC) block A and a thermosensitive BC diblock of recombinant elastin-like polypeptides (ELPs). The triblock in diluted solution (0.1–0.3% w/v), at low temperatures in ultrapure water, forms micellar structures of 10–60 nm sizes in diameter as characterized by dynamic light scattering (DLS) and liquid atomic force microscopy (AFM). While heated above its transition temperature (Tt), larger particles of 200–300 nm sizes are obtained, consistent with the formation of coacervates. When concentrated, the viscosity of the triblock copolymer solution progressively increases, giving a free-standing gel at 4% w/v formed by a network of micron-sized particles. The formed hydrogels are thermally reversible, and their sol–gel transitions are fast and sharp. The gel formation mechanism appears to interestingly biomimic tropoelastin, the native monomeric form of natural elastin, as demonstrated by optical and cryogenic-scanning electron microscopy (cryo-SEM) imaging. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.source | crossref | |
dc.subject.en | Solution chemistry | |
dc.subject.en | Peptides and proteins | |
dc.subject.en | Copolymers | |
dc.subject.en | Hydrogels | |
dc.subject.en | Polymers | |
dc.title.en | Thermosensitive Hybrid Elastin-like Polypeptide-Based ABC Triblock Hydrogel | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1021/acs.macromol.0c01744 | en_US |
dc.subject.hal | Chimie/Polymères | en_US |
bordeaux.journal | Macromolecules | en_US |
bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | en_US |
bordeaux.institution | Bordeaux INP | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | oui | en_US |
bordeaux.import.source | dissemin | |
hal.identifier | hal-03088035 | |
hal.version | 1 | |
hal.date.transferred | 2020-12-24T17:05:18Z | |
hal.export | true | |
workflow.import.source | dissemin | |
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