Thermosensitive Hybrid Elastin-like Polypeptide-Based ABC Triblock Hydrogel
DAI, Michèle
L'Oréal Recherche France [L'Oréal Recherche]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
L'Oréal Recherche France [L'Oréal Recherche]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
GOUDOUNET, Guillaume
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
ZHAO, Hang
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
See more >
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
DAI, Michèle
L'Oréal Recherche France [L'Oréal Recherche]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
L'Oréal Recherche France [L'Oréal Recherche]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
GOUDOUNET, Guillaume
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
ZHAO, Hang
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
GARBAY, Bertrand
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
GARANGER, Elisabeth
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
PECASTAINGS, Gilles
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Reduce
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Language
EN
Article de revue
This item was published in
Macromolecules. 2020-11-23
English Abstract
We report the synthesis of a well-defined hybrid ABC triblock terpolymer containing a synthetic poly(trimethylene carbonate) (PTMC) block A and a thermosensitive BC diblock of recombinant elastin-like polypeptides (ELPs). ...Read more >
We report the synthesis of a well-defined hybrid ABC triblock terpolymer containing a synthetic poly(trimethylene carbonate) (PTMC) block A and a thermosensitive BC diblock of recombinant elastin-like polypeptides (ELPs). The triblock in diluted solution (0.1–0.3% w/v), at low temperatures in ultrapure water, forms micellar structures of 10–60 nm sizes in diameter as characterized by dynamic light scattering (DLS) and liquid atomic force microscopy (AFM). While heated above its transition temperature (Tt), larger particles of 200–300 nm sizes are obtained, consistent with the formation of coacervates. When concentrated, the viscosity of the triblock copolymer solution progressively increases, giving a free-standing gel at 4% w/v formed by a network of micron-sized particles. The formed hydrogels are thermally reversible, and their sol–gel transitions are fast and sharp. The gel formation mechanism appears to interestingly biomimic tropoelastin, the native monomeric form of natural elastin, as demonstrated by optical and cryogenic-scanning electron microscopy (cryo-SEM) imaging.Read less <
English Keywords
Solution chemistry
Peptides and proteins
Copolymers
Hydrogels
Polymers