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dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPASIN, Chloe
dc.contributor.authorHALLORAN, M. E.
dc.contributor.authorGILBERT, P. B.
dc.contributor.authorLANGEVIN, E.
dc.contributor.authorOCHIAI, R. L.
dc.contributor.authorPITISUTTITHUM, P.
dc.contributor.authorCAPEDING, M. R.
dc.contributor.authorCARRASQUILLA, G.
dc.contributor.authorFRAGO, C.
dc.contributor.authorCORTES, M.
dc.contributor.authorCHAMBONNEAU, L.
dc.contributor.authorMOODIE, Z.
dc.date.accessioned2020-12-14T12:32:52Z
dc.date.available2020-12-14T12:32:52Z
dc.date.issued2018
dc.identifier.issn1932-6203en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21439
dc.description.abstractEnOBJECTIVE: To evaluate the association of rainy season with overall dengue disease incidence and with the efficacy of the Sanofi Pasteur recombinant, live, attenuated, tetravalent vaccine (CYD-TDV) in two randomized, controlled multicenter phase III clinical trials in Asia and Latin America. METHODS: Rainy seasons were defined for each study site using climatological information from the World Meteorological Organization. The dengue attack rate in the placebo group for each study month was calculated as the number of symptomatic, virologically-confirmed dengue events in a given month divided by the number of participants at risk in the same month. Time-dependent Cox proportional hazard models were used to test whether rainy season was associated with dengue disease and whether it modified vaccine efficacy in each of the two trials and in both of the trials combined. FINDINGS: Rainy season, country, and age were all significantly associated with dengue disease in both studies. Vaccine efficacy did not change during the rainy season in any of the analyses. CONCLUSIONS: Although dengue transmission and exposure are expected to increase during the rainy season, our results indicate that CYD-TDV vaccine efficacy remains constant throughout the year in endemic regions.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enSISTM
dc.title.enPeriods of high dengue transmission defined by rainfall do not impact efficacy of dengue vaccine in regions of endemic disease
dc.title.alternativePLoS Oneen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pone.0207878en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30543657en_US
bordeaux.journalPLoS ONEen_US
bordeaux.pagee0207878en_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSISTM_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03064389
hal.version1
hal.date.transferred2020-12-14T12:32:59Z
hal.exporttrue
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