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Double-hit or dual expression of MYC and BCL2 in primary cutaneous large B-cell lymphomas

dc.rights.licenseopenen_US
dc.contributor.authorMENGUY, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFRISON, Éric
dc.contributor.authorPROCHAZKOVA-CARLOTTI, M.
dc.contributor.authorDALLE, S.
dc.contributor.authorDEREURE, O.
dc.contributor.authorBOULINGUEZ, S.
dc.contributor.authorDALAC, S.
dc.contributor.authorMACHET, L.
dc.contributor.authorRAM-WOLFF, C.
dc.contributor.authorVERNEUIL, L.
dc.contributor.authorGROS, A.
dc.contributor.authorVERGIER, B.
dc.contributor.authorBEYLOT-BARRY, M.
dc.contributor.authorMERLIO, J. P.
dc.contributor.authorPHAM-LEDARD, A.
dc.date.accessioned2020-12-07T14:49:03Z
dc.date.available2020-12-07T14:49:03Z
dc.date.issued2018-08
dc.identifier.issn1530-0285 (Electronic) 0893-3952 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21331
dc.description.abstractEnIn nodal diffuse large B-cell lymphoma, the search for double-hit with MYC and BCL2 and/or BCL6 rearrangements or for dual expression of BCL2 and MYC defines subgroups of patients with altered prognosis that has not been evaluated in primary cutaneous large B-cell lymphoma. Our objectives were to assess the double-hit and dual expressor status in a cohort of 44 patients with primary cutaneous large B-cell lymphoma according to the histological subtype and to evaluate their prognosis relevance. The 44 cases defined by the presence of more than 80% of large B-cells in the dermis corresponded to 21 primary cutaneous follicle centre lymphoma with large cell morphology and 23 primary cutaneous diffuse large B-cell lymphoma, leg type. Thirty-one cases (70%) expressed BCL2 and 29 (66%) expressed MYC. Dual expressor profile was observed in 25 cases (57%) of either subtypes (n = 6 or n = 19, respectively). Only one primary cutaneous follicle centre lymphoma, large-cell case had a double-hit status (2%). Specific survival was significantly worse in primary cutaneous diffuse large B-cell lymphoma, leg type than in primary cutaneous follicle centre lymphoma, large cell (p = 0.021) and for the dual expressor primary cutaneous large B-cell lymphoma group (p = 0.030). Both overall survival and specific survival were worse for patients belonging to the dual expressor primary cutaneous diffuse large B-cell lymphoma, leg type subgroup (p = 0.001 and p = 0.046, respectively). Expression of either MYC and/or BCL2 negatively impacted overall survival (p = 0.017 and p = 0.018 respectively). As the differential diagnosis between primary cutaneous follicle centre lymphoma, large cell and primary cutaneous diffuse large B-cell lymphoma, leg type has a major impact on prognosis, dual-expression of BCL2 and MYC may represent a new diagnostic criterion for primary cutaneous diffuse large B-cell lymphoma, leg type subtype and further identifies patients with impaired survival. Finally, the double-hit assessment does not appear clinically relevant in primary cutaneous large B-cell lymphoma.
dc.language.isoENen_US
dc.subject.enUSMR
dc.title.enDouble-hit or dual expression of MYC and BCL2 in primary cutaneous large B-cell lymphomas
dc.title.alternativeMod Patholen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41379-018-0041-7en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29581544en_US
bordeaux.journalModern pathologyen_US
bordeaux.page1332-1342en_US
bordeaux.volume31en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamUSMRen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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