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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

dc.rights.licenseopenen_US
dc.contributor.authorMALIK, R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHAUHAN, Ganesh
dc.contributor.authorTRAYLOR, M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSARGURUPREMRAJ, Muralidharan
dc.contributor.authorOKADA, Y.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMISHRA, Aniket
dc.contributor.authorRUTTEN-JACOBS, L.
dc.contributor.authorGIESE, A. K.
dc.contributor.authorVAN DER LAAN, S. W.
dc.contributor.authorGRETARSDOTTIR, S.
dc.contributor.authorANDERSON, C. D.
dc.contributor.authorCHONG, M.
dc.contributor.authorADAMS, H. H. H.
dc.contributor.authorAGO, T.
dc.contributor.authorALMGREN, P.
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorAY, H.
dc.contributor.authorBARTZ, T. M.
dc.contributor.authorBENAVENTE, O. R.
dc.contributor.authorBEVAN, S.
dc.contributor.authorBONCORAGLIO, G. B.
dc.contributor.authorBROWN, R. D., Jr.
dc.contributor.authorBUTTERWORTH, A. S.
dc.contributor.authorCARRERA, C.
dc.contributor.authorCARTY, C. L.
dc.contributor.authorCHASMAN, D. I.
dc.contributor.authorCHEN, W. M.
dc.contributor.authorCOLE, J. W.
dc.contributor.authorCORREA, A.
dc.contributor.authorCOTLARCIUC, I.
dc.contributor.authorCRUCHAGA, C.
dc.contributor.authorDANESH, J.
dc.contributor.authorDE BAKKER, P. I. W.
dc.contributor.authorDESTEFANO, A. L.
dc.contributor.authorDEN HOED, M.
dc.contributor.authorDUAN, Q.
dc.contributor.authorENGELTER, S. T.
dc.contributor.authorFALCONE, G. J.
dc.contributor.authorGOTTESMAN, R. F.
dc.contributor.authorGREWAL, R. P.
dc.contributor.authorGUDNASON, V.
dc.contributor.authorGUSTAFSSON, S.
dc.contributor.authorHAESSLER, J.
dc.contributor.authorHARRIS, T. B.
dc.contributor.authorHASSAN, A.
dc.contributor.authorHAVULINNA, A. S.
dc.contributor.authorHECKBERT, S. R.
dc.contributor.authorHOLLIDAY, E. G.
dc.contributor.authorHOWARD, G.
dc.contributor.authorHSU, F. C.
dc.contributor.authorHYACINTH, H. I.
dc.contributor.authorIKRAM, M. A.
dc.contributor.authorINGELSSON, E.
dc.contributor.authorIRVIN, M. R.
dc.contributor.authorJIAN, X.
dc.contributor.authorJIMENEZ-CONDE, J.
dc.contributor.authorJOHNSON, J. A.
dc.contributor.authorJUKEMA, J. W.
dc.contributor.authorKANAI, M.
dc.contributor.authorKEENE, K. L.
dc.contributor.authorKISSELA, B. M.
dc.contributor.authorKLEINDORFER, D. O.
dc.contributor.authorKOOPERBERG, C.
dc.contributor.authorKUBO, M.
dc.contributor.authorLANGE, L. A.
dc.contributor.authorLANGEFELD, C. D.
dc.contributor.authorLANGENBERG, C.
dc.contributor.authorLAUNER, L. J.
dc.contributor.authorLEE, J. M.
dc.contributor.authorLEMMENS, R.
dc.contributor.authorLEYS, D.
dc.contributor.authorLEWIS, C. M.
dc.contributor.authorLIN, W. Y.
dc.contributor.authorLINDGREN, A. G.
dc.contributor.authorLORENTZEN, E.
dc.contributor.authorMAGNUSSON, P. K.
dc.contributor.authorMAGUIRE, J.
dc.contributor.authorMANICHAIKUL, A.
dc.contributor.authorMCARDLE, P. F.
dc.contributor.authorMESCHIA, J. F.
dc.contributor.authorMITCHELL, B. D.
dc.contributor.authorMOSLEY, T. H.
dc.contributor.authorNALLS, M. A.
dc.contributor.authorNINOMIYA, T.
dc.contributor.authorO'DONNELL, M. J.
dc.contributor.authorPSATY, B. M.
dc.contributor.authorPULIT, S. L.
dc.contributor.authorRANNIKMAE, K.
dc.contributor.authorREINER, A. P.
dc.contributor.authorREXRODE, K. M.
dc.contributor.authorRICE, K.
dc.contributor.authorRICH, S. S.
dc.contributor.authorRIDKER, P. M.
dc.contributor.authorROST, N. S.
dc.contributor.authorROTHWELL, P. M.
dc.contributor.authorROTTER, J. I.
dc.contributor.authorRUNDEK, T.
dc.contributor.authorSACCO, R. L.
dc.contributor.authorSAKAUE, S.
dc.contributor.authorSALE, M. M.
dc.contributor.authorSALOMAA, V.
dc.contributor.authorSAPKOTA, B. R.
dc.contributor.authorSCHMIDT, R.
dc.contributor.authorSCHMIDT, C. O.
dc.contributor.authorSCHMINKE, U.
dc.contributor.authorSHARMA, P.
dc.contributor.authorSLOWIK, A.
dc.contributor.authorSUDLOW, C. L. M.
dc.contributor.authorTANISLAV, C.
dc.contributor.authorTATLISUMAK, T.
dc.contributor.authorTAYLOR, K. D.
dc.contributor.authorTHIJS, V. N. S.
dc.contributor.authorTHORLEIFSSON, G.
dc.contributor.authorTHORSTEINSDOTTIR, U.
dc.contributor.authorTIEDT, S.
dc.contributor.authorTROMPET, S.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
dc.contributor.authorVAN DUIJN, C. M.
dc.contributor.authorWALTERS, M.
dc.contributor.authorWAREHAM, N. J.
dc.contributor.authorWASSERTHEIL-SMOLLER, S.
dc.contributor.authorWILSON, J. G.
dc.contributor.authorWIGGINS, K. L.
dc.contributor.authorYANG, Q.
dc.contributor.authorYUSUF, S.
dc.contributor.authorBIS, J. C.
dc.contributor.authorPASTINEN, T.
dc.contributor.authorRUUSALEPP, A.
dc.contributor.authorSCHADT, E. E.
dc.contributor.authorKOPLEV, S.
dc.contributor.authorBJORKEGREN, J. L. M.
dc.contributor.authorCODONI, V.
dc.contributor.authorCIVELEK, M.
dc.contributor.authorSMITH, N. L.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTREGOUET, David-Alexandre
dc.contributor.authorCHRISTOPHERSEN, I. E.
dc.contributor.authorROSELLI, C.
dc.contributor.authorLUBITZ, S. A.
dc.contributor.authorELLINOR, P. T.
dc.contributor.authorTAI, E. S.
dc.contributor.authorKOONER, J. S.
dc.contributor.authorKATO, N.
dc.contributor.authorHE, J.
dc.contributor.authorVAN DER HARST, P.
dc.contributor.authorELLIOTT, P.
dc.contributor.authorCHAMBERS, J. C.
dc.contributor.authorTAKEUCHI, F.
dc.contributor.authorJOHNSON, A. D.
dc.contributor.authorSANGHERA, D. K.
dc.contributor.authorMELANDER, O.
dc.contributor.authorJERN, C.
dc.contributor.authorSTRBIAN, D.
dc.contributor.authorFERNANDEZ-CADENAS, I.
dc.contributor.authorLONGSTRETH, W. T., Jr.
dc.contributor.authorROLFS, A.
dc.contributor.authorHATA, J.
dc.contributor.authorWOO, D.
dc.contributor.authorROSAND, J.
dc.contributor.authorPARE, G.
dc.contributor.authorHOPEWELL, J. C.
dc.contributor.authorSALEHEEN, D.
dc.contributor.authorSTEFANSSON, K.
dc.contributor.authorWORRALL, B. B.
dc.contributor.authorKITTNER, S. J.
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorFORNAGE, M.
dc.contributor.authorMARKUS, H. S.
dc.contributor.authorHOWSON, J. M. M.
dc.contributor.authorKAMATANI, Y.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDICHGANS, M.
dc.date.accessioned2020-12-01T10:46:39Z
dc.date.available2020-12-01T10:46:39Z
dc.date.issued2018-03-12
dc.identifier.issn1546-1718 (Electronic) 1061-4036 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/21276
dc.description.abstractEnStroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.
dc.language.isoENen_US
dc.subject.enSEPIA
dc.subject.enVINTAGE
dc.title.enMultiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
dc.title.alternativeNat Geneten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41588-018-0058-3en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29531354en_US
bordeaux.journalNature Geneticsen_US
bordeaux.page524-537en_US
bordeaux.volume50en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamSEPIAen_US
bordeaux.teamVINTAGEen_US
bordeaux.teamHEALTHY_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03193074
hal.version1
hal.date.transferred2021-04-08T13:29:56Z
hal.exporttrue
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