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Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture
| dc.rights.license | open | en_US |
| dc.contributor.author | LUNEMANN, S. | |
| dc.contributor.author | SCHOBEL, A. | |
| dc.contributor.author | KAH, J. | |
| dc.contributor.author | FITTJE, P. | |
| dc.contributor.author | HOLZEMER, A. | |
| dc.contributor.author | LANGENECKERT, A. E. | |
| dc.contributor.author | HESS, L. U. | |
| dc.contributor.author | POCH, T. | |
| dc.contributor.author | MARTRUS, G. | |
| dc.contributor.author | GARCIA-BELTRAN, W. F. | |
| dc.contributor.author | KORNER, C. | |
| dc.contributor.author | ZIEGLER, A. E. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RICHERT, Laura | |
| dc.contributor.author | OLDHAFER, K. J. | |
| dc.contributor.author | SCHULZE ZUR WIESCH, J. | |
| dc.contributor.author | SCHRAMM, C. | |
| dc.contributor.author | DANDRI, M. | |
| dc.contributor.author | HERKER, E. | |
| dc.contributor.author | ALTFELD, M. | |
| dc.date.accessioned | 2020-11-30T14:06:26Z | |
| dc.date.available | 2020-11-30T14:06:26Z | |
| dc.date.issued | 2018-11 | |
| dc.identifier.issn | 1528-0012 (Electronic) 0016-5085 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/21267 | |
| dc.description.abstractEn | Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers, and primary liver tissue from HCV-infected individuals, we found that the KIR3DS1 ligand HLA-F is up-regulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | SISTM | |
| dc.title.en | Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture | |
| dc.title.alternative | Gastroenterology | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1053/j.gastro.2018.07.019 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 30031767 | en_US |
| bordeaux.journal | Gastroenterology | en_US |
| bordeaux.page | 1366-1371.e3 | en_US |
| bordeaux.volume | 155 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | SISTM | en_US |
| bordeaux.team | SISTM_BPH | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.export | false | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Gastroenterology&rft.date=2018-11&rft.volume=155&rft.issue=5&rft.spage=1366-1371.e3&rft.epage=1366-1371.e3&rft.eissn=1528-0012%20(Electronic)%200016-5085%20(Linking)&rft.issn=1528-0012%20(Electronic)%200016-5085%20(Linking)&rft.au=LUNEMANN,%20S.&SCHOBEL,%20A.&KAH,%20J.&FITTJE,%20P.&HOLZEMER,%20A.&rft.genre=article |
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