DEWITTE, A.; LEPREUX, S.; VILLENEUVE, J.; RIGOTHIER, C.; COMBE, C.; OUATTARA, A.; RIPOCHE, H.

doi:10.1186/s13613-017-0337-7

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Article de revue

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Ann Intensive Care. 2017, vol. 7(1):115

Resumen en inglés

Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened the spectrum of their role in health and disease. Here, we propose a narrative review that first describes these new platelet attributes. We then examine their relevance to microcirculatory alterations in multi-organ dysfunction, a major sepsis complication. Rapid progresses that are made on the knowledge of novel platelet functions should improve the understanding of thrombocytopenia, a common condition and a predictor of adverse outcome in sepsis, and may provide potential avenues for management and therapy.< Leer menos

Palabras clave

*Article CLINIQUE

Palabras clave en inglés

Inflammation

Intensive care

Platelets

Sepsis

URI

https://oskar-bordeaux.fr/handle/20.500.12278/21225

DOI

http://dx.doi.org/10.1186/s13613-017-0337-7

Centros de investigación

Biologie des maladies cardiovasculaires (BMC) - UMR 1034

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Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?