Afficher la notice abrégée

New markers for early detection of acute kidney injury after transcatheter aortic valve implantation

dc.rights.licenseopenen_US
dc.contributor.authorZAOUTER, Cédrick
dc.contributor.authorPRIEM, Frédérique
dc.contributor.authorLEROUX, Lionel
dc.contributor.authorBONNET, Guillaume
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorBATS, Marie-Lise
dc.contributor.authorBEAUVIEUX, Marie-Christine
dc.contributor.authorRÉMY, Alain
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorOUATTARA, Alexandre
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2018
dc.identifier.issn2352-5568en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20877
dc.description.abstractEnAbstract BACKGROUND: Acute kidney injury (AKI) is a frequent complication after a transcatheter aortic valve implantation (TAVI). Biomarkers such as urinary G1 cell cycle arrest proteins (TIMP-2 and IGFBP7) and sonographic evaluation (Doppler Renal Resistive Index [RRI]) have been advocated to predict AKI at an early stage after a TAVI-procedure. The primary aim was to determine the predictive value of these markers to detect AKI after a TAVI-procedure at an early phase. PATIENTS AND METHODS: In a prospective observational study, 62 consecutive patients were scheduled for a TAVI. AKI was assessed based on the KDIGO criteria. Biomarkers and RRI were measured concomitantly before TAVI, at the first micturition post-implantation and the first micturition on the morning after the procedure. RESULTS: Twenty-two patients (35%) developed AKI. On the first day after the TAVI-procedure, urinary TIMP-2 and IGFBP7 concentrations increased significantly in patients who developed AKI (0.1, [interquartile] [0.1-0.35] to 0.40 [0.10-1.00] vs. 0.2 [0.1-0.5] to 0.10 [0.10-0.20], P=0.012) with an area under the receiver-operating characteristic curve of 0.71 [0.55-0.83]. Sensitivity was 0.57 and specificity was 0.83 for a cut-off value of 0.35. No significant increases in RRI were found in patients who developed AKI. CONCLUSIONS: Based on the current guidelines for the diagnosis of AKI, the urinary proteins TIMP-2 and IGFBP7 do not detect AKI at an early stage accurately in patients undergoing a TAVI-procedure.
dc.language.isoENen_US
dc.subjectArticle CLINIQUE
dc.title.enNew markers for early detection of acute kidney injury after transcatheter aortic valve implantation
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.accpm.2017.10.004en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalAnaesthesia Critical Care & Pain Medicineen_US
bordeaux.page319–326en_US
bordeaux.volume37en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires - U1034en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Anaesthesia%20Critical%20Care%20&%20Pain%20Medicine&rft.date=2018&rft.volume=37&rft.issue=4&rft.spage=319%E2%80%93326&rft.epage=319%E2%80%93326&rft.eissn=2352-5568&rft.issn=2352-5568&rft.au=ZAOUTER,%20C%C3%A9drick&PRIEM,%20Fr%C3%A9d%C3%A9rique&LEROUX,%20Lionel&BONNET,%20Guillaume&BATS,%20Marie-Lise&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée