Global changes have profoundly altered the interactions between pathogens and their hosts, accelerating the emergence of infectious diseases. Monitoring vector-borne infectious diseases is therefore challenging and requires an upgrading of the detection system relying mainly nowadays on passive surveillance and reactive measures when a human case is diagnosed. West Nile virus (WNV) and Usutu virus are 2 zoonotic orthoflaviviruses, maintained between bird populations and mosquitoes, threatening public and veterinary health in Europe. In 2022, WNV unexpectedly emerged on the Atlantic coast of France in equids. Following this emergence, a consortium of national and local actors from the Nouvelle-Aquitaine region conducted crucial operational research, integrating environmental and animal data to make timely evidence-based and territorialized decisions to better assess the risk to human health. The proposal outlines the creation of a novel collaborative effort uniting experts from veterinary, human, and environmental health, as well as policy-makers. This partnership aims to establish a sustainable framework to address persistent knowledge gaps in our comprehension of arboviral disease emergence. By integrating diverse scientific disciplines with institutional decision-making processes, the initiative seeks to enhance our understanding of the complex factors contributing to the emergence and spread of arboviral diseases.< Leer menos