Polycaprolactone-b-poly(ethylene oxide) biocompatible micelles as dynamic light scattering drug delivery nanocarriers: Dynamic light scattering and fluorescence experiments
BORSALI, Redouane
Laboratoire de Chimie des polymères organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des polymères organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
BORSALI, Redouane
Laboratoire de Chimie des polymères organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Reduce
Laboratoire de Chimie des polymères organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Language
en
Article de revue
This item was published in
Macromolecular Symposia. 2005, vol. 229, p. 107-117
Wiley-VCH Verlag
English Abstract
Dynamic light scattering (DLS) and fluorescence experiments were carried out to study PCL44-b-PEO114 biocompatible micelles used as nanocarriers in drug delivery. Micelles prepared by a simple procedure (THF removal under ...Read more >
Dynamic light scattering (DLS) and fluorescence experiments were carried out to study PCL44-b-PEO114 biocompatible micelles used as nanocarriers in drug delivery. Micelles prepared by a simple procedure (THF removal under nitrogen flow) exhibited a narrow size distribution with an average diameter of 100nm. For micelles containing a hydrophobic model compound (pyrene) within the PCL core, a smaller average micellar size of 80 nm was observed, with a simultaneous broadening in the size distribution profile. in parallel to DLS results, fluorescence experiments showed evidence of pyrene encapsulation, and that the onset of the micellization process occurs at approximately 10/90 (v/v) THF/water mixtures in the case of PCL44-b-PEO114 polymer.Read less <
English Keywords
PCL-b-PEO
dynamic light scattering (DLS)
fluorescence
micelles
drug delivery systems
Origin
Hal imported