QUEMENER, Damien; HÉROGUEZ, Valérie; GNANOU, Yves

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QUEMENER, Damien
Laboratoire de Chimie des polymères organiques [LCPO]

HÉROGUEZ, Valérie
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering

GNANOU, Yves
Laboratoire de Chimie des polymères organiques [LCPO]

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Journal of Polymer Science Part A: Polymer Chemistry. 2005, vol. 43, n° 1, p. 217-229

Wiley

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This study describes the synthesis of polynorbornene colloidal particles able to release active molecules in response to pH change. Such functionalized polynorbornene latices with surface active molecules have been obtained by ring-opening metathesis copolymerization in a dichloromethane/ethanol medium in the presence of alpha-norbornenyl poly(ethylene oxide) macromonomer. Two different strategies of introduction of the active molecule-either at their periphery or at their core- have been contemplated. The particles have been characterized by both dynamic light scattering and transmission electron microscopy. Their size was found to range from 260 to 600 nm. The release of the active molecules was monitored by UV spectrometry. After 48 h in an appropriate HCl buffer (pH = 3) more than 80% of the initially linked active molecule was released.< Leer menos

Palabras clave en inglés

latices

ROMP

drug delivery systems

dispersion polymerization

ring-opening metathesis polymerization

functionalized latices

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Synthesis of acid-sensitive latices by ring-opening metathesis polymerization

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