Synthesis of acid-sensitive latices by ring-opening metathesis polymerization
HÉROGUEZ, Valérie
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
HÉROGUEZ, Valérie
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
< Reduce
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Language
en
Article de revue
This item was published in
Journal of Polymer Science Part A: Polymer Chemistry. 2005, vol. 43, n° 1, p. 217-229
Wiley
English Abstract
This study describes the synthesis of polynorbornene colloidal particles able to release active molecules in response to pH change. Such functionalized polynorbornene latices with surface active molecules have been obtained ...Read more >
This study describes the synthesis of polynorbornene colloidal particles able to release active molecules in response to pH change. Such functionalized polynorbornene latices with surface active molecules have been obtained by ring-opening metathesis copolymerization in a dichloromethane/ethanol medium in the presence of alpha-norbornenyl poly(ethylene oxide) macromonomer. Two different strategies of introduction of the active molecule-either at their periphery or at their core- have been contemplated. The particles have been characterized by both dynamic light scattering and transmission electron microscopy. Their size was found to range from 260 to 600 nm. The release of the active molecules was monitored by UV spectrometry. After 48 h in an appropriate HCl buffer (pH = 3) more than 80% of the initially linked active molecule was released.Read less <
English Keywords
latices
ROMP
drug delivery systems
dispersion polymerization
ring-opening metathesis polymerization
functionalized latices
Origin
Hal imported