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Biomimetic doxorubicin loaded polymersomes from hyaluronan-block-poly(gamma-benzyl glutamate) copolymers

dc.rights.licenseopen
hal.structure.identifierPharm Dept, Fac Technol & Eng, Univ Baroda
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorUPADHYAY, Kamal Kumar
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-Francois
hal.structure.identifierPharm Dept, Fac Technol & Eng, Univ Baroda
dc.contributor.authorMISRA, A.
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorVOISIN, Pierre
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorBOUCHAUD, Véronique
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorIBARBOURE, Emmanuel
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSCHATZ, Christophe
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2009
dc.identifier.issn1525-7797
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20624
dc.description.abstractEnUsing "click chemistry" as an easy and versatile synthetic strategy to combine hyaluronan and polyglutamate blocks, we have prepared nanovesicles (polymersomes) that present a controlled size, excellent colloidal stability, and a high loading capacity for hydrophilic and hydrophobic drugs. The unique feature of our concept is the use of hyaluronan, a polysaccharide with known capacity for targeting cancer-related protein receptors, as the hydrophilic portion of a block copolymer system. The cytotoxicity and internalization mechanism of doxorubicin-loaded polymersomes have been evaluated in C6 glioma tumor cell lines. The dual purpose served by hyaluronan, as both a hydrophilic block critical to vesicle formation and as a binding agent for biological targets, breaks new ground in terms of multifunctional nanomaterial design for drug delivery.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enbiomimetic
dc.subject.entargeting
dc.subject.envesicle
dc.subject.enblock copolymer
dc.subject.enpolysaccharide
dc.subject.enpolypeptide
dc.title.enBiomimetic doxorubicin loaded polymersomes from hyaluronan-block-poly(gamma-benzyl glutamate) copolymers
dc.typeArticle de revue
dc.identifier.doi10.1021/bm9006419
dc.subject.halChimie/Polymères
bordeaux.journalBiomacromolecules
bordeaux.page2802-2808
bordeaux.volume10
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue10
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00400384
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00400384v1
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