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Role of Block Copolymer Nanoconstructs in Cancer Therapy

dc.rights.licenseopen
hal.structure.identifierPharm Dept, Fac Technol & Eng, Univ Baroda
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorUPADHYAY, Kamal Kumar
hal.structure.identifierPharm Dept, Fac Technol & Eng, Univ Baroda
dc.contributor.authorAGRAWAL, H.
hal.structure.identifierPharm Dept, Fac Technol & Eng, Univ Baroda
dc.contributor.authorUPADHYAY, C.
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSCHATZ, Christophe
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLE MEINS, Jean-Francois
hal.structure.identifierPharm Dept, Fac Technol & Eng, Univ Baroda
dc.contributor.authorMISRA, A.
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2009
dc.identifier.issn0743-4863
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20623
dc.description.abstractEnDrug, gene and protein delivery is a very challenging and exciting area in nanobiotechnology where block copolymers are increasingly considered especially as carriers for chemotherapeutic agents in treatment of various cancers. Cancer chemotherapy is particularly challenging because of nonselective distribution of drugs, associated severe toxicity, multidrug resistance and chronic treatments influencing the quality-adjusted life of patients. These limitations lead to incomplete cure and render many drugs ineffective in treating cancers. Liposomes are currently more advanced in clinical trials and industrial developments but they lack stability and pose difficulties in functionalizing it. More recently, various types of polymer-based nano-constructs have been designed, synthesized and used for the cancer chemotherapy applications. This review discusses the most significant and recent literature developments on specific self-assembled block copolymers as a carrier system such as micelles and vesicles, which can be successfully used to enhance the solubility of hydrophobic drugs, helpful in targeting selective sites in the body, delivering active molecules in a control manner and reducing the side effects, and their role in treatment of cancer.
dc.language.isoen
dc.publisherBegell House
dc.subject.enliposomes
dc.subject.enself-assembled block copolymers
dc.subject.enpolymer-based nanoconstructs
dc.subject.enpolymeric vesicles
dc.subject.enchemotherapeutic agents
dc.subject.entargeting
dc.subject.ensolubility
dc.subject.enmicelles
dc.subject.envesicles
dc.title.enRole of Block Copolymer Nanoconstructs in Cancer Therapy
dc.typeArticle de revue
dc.subject.halChimie/Polymères
bordeaux.journalCritical Reviews in Therapeutic Drug Carrier Systems
bordeaux.page157-205
bordeaux.volume26
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue2
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00400394
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00400394v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Critical%20Reviews%20in%20Therapeutic%20Drug%20Carrier%20Systems&rft.date=2009&rft.volume=26&rft.issue=2&rft.spage=157-205&rft.epage=157-205&rft.eissn=0743-4863&rft.issn=0743-4863&rft.au=UPADHYAY,%20Kamal%20Kumar&AGRAWAL,%20H.&UPADHYAY,%20C.&SCHATZ,%20Christophe&LE%20MEINS,%20Jean-Francois&rft.genre=article


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