Role of Block Copolymer Nanoconstructs in Cancer Therapy
UPADHYAY, Kamal Kumar
Pharm Dept, Fac Technol & Eng, Univ Baroda
Laboratoire de Chimie des Polymères Organiques [LCPO]
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Pharm Dept, Fac Technol & Eng, Univ Baroda
Laboratoire de Chimie des Polymères Organiques [LCPO]
UPADHYAY, Kamal Kumar
Pharm Dept, Fac Technol & Eng, Univ Baroda
Laboratoire de Chimie des Polymères Organiques [LCPO]
Pharm Dept, Fac Technol & Eng, Univ Baroda
Laboratoire de Chimie des Polymères Organiques [LCPO]
SCHATZ, Christophe
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
LE MEINS, Jean-Francois
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Réduire
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Langue
en
Article de revue
Ce document a été publié dans
Critical Reviews in Therapeutic Drug Carrier Systems. 2009, vol. 26, n° 2, p. 157-205
Begell House
Résumé en anglais
Drug, gene and protein delivery is a very challenging and exciting area in nanobiotechnology where block copolymers are increasingly considered especially as carriers for chemotherapeutic agents in treatment of various ...Lire la suite >
Drug, gene and protein delivery is a very challenging and exciting area in nanobiotechnology where block copolymers are increasingly considered especially as carriers for chemotherapeutic agents in treatment of various cancers. Cancer chemotherapy is particularly challenging because of nonselective distribution of drugs, associated severe toxicity, multidrug resistance and chronic treatments influencing the quality-adjusted life of patients. These limitations lead to incomplete cure and render many drugs ineffective in treating cancers. Liposomes are currently more advanced in clinical trials and industrial developments but they lack stability and pose difficulties in functionalizing it. More recently, various types of polymer-based nano-constructs have been designed, synthesized and used for the cancer chemotherapy applications. This review discusses the most significant and recent literature developments on specific self-assembled block copolymers as a carrier system such as micelles and vesicles, which can be successfully used to enhance the solubility of hydrophobic drugs, helpful in targeting selective sites in the body, delivering active molecules in a control manner and reducing the side effects, and their role in treatment of cancer.< Réduire
Mots clés en anglais
liposomes
self-assembled block copolymers
polymer-based nanoconstructs
polymeric vesicles
chemotherapeutic agents
targeting
solubility
micelles
vesicles
Origine
Importé de halUnités de recherche