Afficher la notice abrégée

Vectorisation et délivrance ciblée de médicaments ou gènes inductibles par des nanoparticules sensibles à l'hyperthermie sous contrôle de l'IRM - NanoBioImaging

dc.rights.licenseopen
hal.structure.identifierNeuroinflammation: imagerie et thérapie de la sclérose en plaques
dc.contributor.authorPETRY, Klaus
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorVOISIN, Pierre
hal.structure.identifierImagerie Moléculaire et Nanobiotechnologies - Institut Européen de Chimie et Biologie [IECB]
dc.contributor.authorBRISSON, Alain
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDUGUET, Etienne
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorFRANCONI, Jean-Michel
hal.structure.identifierSociété Guerbetx
dc.contributor.authorIDÉE, Jean-Marc
hal.structure.identifierNeuroinflammation: imagerie et thérapie de la sclérose en plaques
dc.contributor.authorBOIZIAU, Claudine
ORCID: 0000-0002-0475-2571
IDREF: 85228370
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2011
dc.identifier.issn1959-0318
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20567
dc.description.abstractEnIn experimental models of glioblastoma and Multiple sclerosis, we took advantage of molecular alterations of the neurovascular cells to address specific targeting via immune cells (monocytes, microglia) and ligands (antibodies and newly screened peptide ligands). The microglia cells were manipulated ex vivo for the heat sensitive expression of a therapeutic gene and incorporated a heat sensitive magnetic contrast agent. The ligands were labelled to carry both a magnetic contrast agent integrated in a heat sensitive cargo and a fluorescent maker. Upon i.v. administration, the manipulated microglia cells and the molecular ligand constructs targeted respectively, in vivo the tumour sites and the inflammatory alterations of lesions of the central nervous system (CNS) under the in vivo control of MRI that was confirmed by immunohistopathology. The approach is developed to associate target specific therapy and biomarkers in CNS diseases.
dc.language.isoen
dc.publisherElsevier Masson
dc.subject.enMicroglia ligands
dc.subject.enThermosensitive and magnetic nanocargo hybrids MRI
dc.subject.enGlioblastoma multiple sclerosis monocytes
dc.subject.enTargeted delivery
dc.titleVectorisation et délivrance ciblée de médicaments ou gènes inductibles par des nanoparticules sensibles à l'hyperthermie sous contrôle de l'IRM - NanoBioImaging
dc.typeArticle de revue
dc.identifier.doi10.1016/j.irbm.2011.01.034
dc.subject.halChimie/Matériaux
bordeaux.journalInnovation and Research in BioMedical engineering
bordeaux.page185-190
bordeaux.volume32
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue3
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-00618146
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00618146v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.title=Vectorisation%20et%20d%C3%A9livrance%20cibl%C3%A9e%20de%20m%C3%A9dicaments%20ou%20g%C3%A8nes%20inductibles%20par%20des%20nanoparticules%20sensibles%20%C3%A0%20l'hyperther&rft.atitle=Vectorisation%20et%20d%C3%A9livrance%20cibl%C3%A9e%20de%20m%C3%A9dicaments%20ou%20g%C3%A8nes%20inductibles%20par%20des%20nanoparticules%20sensibles%20%C3%A0%20l'hyperthe&rft.jtitle=Innovation%20and%20Research%20in%20BioMedical%20engineering&rft.date=2011&rft.volume=32&rft.issue=3&rft.spage=185-190&rft.epage=185-190&rft.eissn=1959-0318&rft.issn=1959-0318&rft.au=PETRY,%20Klaus&VOISIN,%20Pierre&BRISSON,%20Alain&LECOMMANDOUX,%20Sebastien&DUGUET,%20Etienne&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée