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Polysaccharide-Containing Block Copolymers: Synthesis, Properties and Applications of an Emerging Family of Glycoconjugates

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSCHATZ, Christophe
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.created2010
dc.date.issued2010
dc.identifier.issn1022-1336
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20560
dc.description.abstractEnWhile polysaccharide graft copolymers and glycopolymers have been widely studied and used in various applications, linear block copolymer structures combining a polysaccharide segment and a synthetic one have been less described. The limited availability of the polysaccharide reducing-end, the difficulty of finding a common solvent of both blocks and the need sometimes to protect the lateral hydroxyl groups of the polysaccharide chain may explain the relatively low number of studies on this copolymer family despite its potential interest. Polysaccharide block copolymers feature physicochemical properties not only close to those of synthetic block copolymers but also bring an added value such as the biodegradability, the biocompatibility or the bioactivity in some cases. This review aims at presenting the synthetic pathways towards such structures, from the basic polymerization techniques to the most recent ones including controlled/living polymerization mechanisms and also by emphasizing the chemical reactions used to functionalize the reducing-end of the polysaccharide block. The amphiphilic nature of most of the polysaccharide-based block copolymers reported so far gives rise to various self-assembly morphologies in the solid state or in selective solvents. In addition, the rigidity of the polysaccharide block is expected to influence the microphase separation of the block copolymer by increasing the thermodynamic incompatibility between dissimilar blocks. A special interest was drawn to the formation and the properties of polymer vesicles (polymersomes) in aqueous solutions. Polysaccharide block copolymers might represent a new class of biomaterials with potential applications in different fields such as the plastic industry, the detergency and also the pharmaceutics where the design of nanodevices carrying a native polysaccharide chain is of interest for therapy, vaccination and diagnosis purposes.
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.subject.enblock copolymers
dc.subject.enpolysaccharides
dc.subject.enself-assembly
dc.subject.enbiodegradability
dc.subject.enbiopolymers
dc.title.enPolysaccharide-Containing Block Copolymers: Synthesis, Properties and Applications of an Emerging Family of Glycoconjugates
dc.typeArticle de revue
dc.identifier.doi10.1002/marc.201000267
dc.subject.halChimie/Polymères
bordeaux.journalMacromolecular Rapid Communications
bordeaux.page1664-1684
bordeaux.volume31
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue19
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00652814
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00652814v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Macromolecular%20Rapid%20Communications&rft.date=2010&rft.volume=31&rft.issue=19&rft.spage=1664-1684&rft.epage=1664-1684&rft.eissn=1022-1336&rft.issn=1022-1336&rft.au=SCHATZ,%20Christophe&LECOMMANDOUX,%20Sebastien&rft.genre=article


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