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dc.rights.licenseopen
hal.structure.identifierTHEME 2
dc.contributor.authorSANSON, Charles
hal.structure.identifierTHEME 2
dc.contributor.authorDIOU, Odile
hal.structure.identifierTHEME 2
dc.contributor.authorTHEVENOT, Julie
hal.structure.identifierTHEME 2
dc.contributor.authorIBARBOURE, Emmanuel
hal.structure.identifierLaboratoire de Chimie des polymères organiques [LCPO]
dc.contributor.authorSOUM, Alain
hal.structure.identifierLaboratoire Léon Brillouin [LLB - UMR 12]
dc.contributor.authorBRÛLET, Annie
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMIRAUX, Sylvain
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorTHIAUDIÈRE, Eric
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorTAN, Sisareuth
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBRISSON, Alain
hal.structure.identifierPhysicochimie des Electrolytes, Colloïdes et Sciences Analytiques [PECSA]
dc.contributor.authorDUPUIS, Vincent
hal.structure.identifierTHEME 2
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierTHEME 2
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.created2011
dc.date.issued2012
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20496
dc.description.abstractEnHydrophobically modified magnetic nanoparticles (MNPs) were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formulation method provides a high loading of MNPs (up to 70 wt %) together with a good control over the sizes of the vesicles (100 - 400 nm). The deformation of the vesicle membrane under an applied magnetic field was evidenced by anisotropic SANS. These hybrid objects display contrast enhancement properties in Magnetic Resonance Imaging, a diagnostic method routinely used for three-dimensional and non-invasive scans of the human body. They can also be guided in a magnetic field gradient. The feasibility of drug release triggered by magnetic induction was evidenced using the anticancer drug doxorubicin (DOX), which is co-encapsulated in the membrane. Magnetic polymersomes are thus proposed as multimodal drug nanocarriers for bio-imaging and magneto-chemotherapy.
dc.language.isoen
dc.title.enDoxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy
dc.typeArticle de revue
dc.subject.halChimie/Matériaux
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
dc.identifier.arxiv1209.5098
dc.description.sponsorshipEuropeFP7 CP-IP 213631-2 NANOTHER
bordeaux.journalLLB Highlights 2011
bordeaux.page48-49
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewednon
hal.identifierhal-00734562
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00734562v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=LLB%20Highlights%202011&rft.date=2012&rft.spage=48-49&rft.epage=48-49&rft.au=SANSON,%20Charles&DIOU,%20Odile&THEVENOT,%20Julie&IBARBOURE,%20Emmanuel&SOUM,%20Alain&rft.genre=article


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